Journal article
Arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle mass
Environment international, Vol.143, pp.105890-105890
10/2020
DOI: 10.1016/j.envint.2020.105890
PMID: 32619914
Abstract
•Arsenic exposure increases fasting blood glucose levels and insulin resistance.•Arsenic exposure causes the reduction of skeletal muscle mass.•Arsenic exposure increased the risk of hyperglycemia.•Females are more susceptible to arsenic -related hyperglycemia than males.•Risk of hyperglycemia is increased with reduction of skeletal muscle mass.
Alargebodyof evidence has shown a link between arsenic exposure and diabetes, but the underlying mechanisms have not yet been clarified.
We explored the association between arsenic exposure and the reduction of skeletal muscle mass as a potential mechanism of insulin resistance for developing arsenic-related hyperglycemia.
A total of 581 subjects were recruited from arsenic-endemic and non-endemic areas in Bangladesh and their fasting blood glucose (FBG), serum insulin, and serum creatinine levels were determined. Subjects’ arsenic exposure levels were assessed by arsenic concentrations in water, hair, and nails. HOMA-IR and HOMA-β were used to calculate insulin resistance and β-cell dysfunction, respectively. Serum creatinine levels and lean body mass (LBM) were used as muscle mass indicators.
Water, hair and nail arsenic concentrations showed significant positive associations with FBG, serum insulin and HOMA-IR and inverse associations with serum creatinine and LBM in a dose-dependent manner both in males and females. Water, hair and nail arsenic showed significant inverse associations with HOMA-β in females but not in males. FBG and HOMA-IR were increased with the decreasing levels of serum creatinine and LBM. Odds ratios (ORs)of hyperglycemia were significantly increased with the increasing concentrations of arsenic in water, hair and nails and with the decreasing levels of serum creatinine and LBM. Females’ HOMA-IR showed greater susceptibility to the reduction of serum creatinine and LBM, possibly causing the greater risk of hyperglycemia in females than males. Path analysis revealed the mediating effect of serum creatinine level on the relationship of arsenic exposure with HOMA-IR and hyperglycemia.
Arsenic exposure elevates FBG levels and the risk of hyperglycemia through increasing insulin resistance with greater susceptibility in females than males. Additionally, arsenic exposure-related reduction of skeletal muscle mass may be a mechanism underlying the development of insulin resistance and hyperglycemia.
Details
- Title: Subtitle
- Arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle mass
- Creators
- Victor Mondal - Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, BangladeshZubaer Hosen - Department of Applied Nutrition and Food Technology, Islamic University, Kushtia 7003, BangladeshFaruk Hossen - Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, BangladeshAbu Eabrahim Siddique - Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, BangladeshSelim Reza Tony - Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, BangladeshZohurul Islam - Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, BangladeshMd. Shofikul Islam - Department of Applied Nutrition and Food Technology, Islamic University, Kushtia 7003, BangladeshShakhawoat Hossain - Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, BangladeshKhairul Islam - Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science & Technology University, Tangail 1902, BangladeshMd. Khalequzzaman Sarker - Department of Gastroenterology, Rajshahi Medical College, Rajshahi 6000, BangladeshM.M Hasibuzzaman - Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, United StatesLing-Zhi Liu - Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United StatesBing-Hua Jiang - Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United StatesMd Mominul Hoque - Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, BangladeshZahangir Alam Saud - Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, BangladeshLian Xin - Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770–8514, JapanSeiichiro Himeno - Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770–8514, JapanKhaled Hossain - Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh
- Resource Type
- Journal article
- Publication Details
- Environment international, Vol.143, pp.105890-105890
- DOI
- 10.1016/j.envint.2020.105890
- PMID
- 32619914
- NLM abbreviation
- Environ Int
- ISSN
- 0160-4120
- eISSN
- 1873-6750
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000066, name: National Institute of Environmental Health Sciences; DOI: 10.13039/501100001691, name: Japan Society for the Promotion of Science
- Language
- English
- Date published
- 10/2020
- Academic Unit
- Pathology; Orthopedics and Rehabilitation; Radiation Oncology
- Record Identifier
- 9984066352202771
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