Journal article
Arterial Stiffness and Pulse-Pressure Amplification in Overweight/Obese African- American Adolescents: Relation With Higher Systolic and Pulse Pressure
American journal of hypertension, Vol.26(1), pp.20-26
01/2013
DOI: 10.1093/ajh/hps014
PMCID: PMC3626033
PMID: 23382323
Abstract
BACKGROUND
Obesity is associated with a higher systolic blood pressure (BP) and pulse pressure (PP) in African-American youths, increasing their risk for developing hypertension. However, it is unknown whether arterial stiffness and wave reflection are associated with a higher systolic BP and PP or with smaller PP amplification in overweight/obese (OW/OB) African-American adolescents.
METHODS
We measured carotid-femoral pulse wave velocity (CF-PWV), carotid-radial PWV (CR-PWV), the augmentation index (AIx) adjusted to a heart rate of 75 bpm (AI75), the augmentation pressure (AugP), PP amplification, and body composition in 227 healthy African-American adolescents (age, 16.9±0.2 years; 54% male).
RESULTS
Adolescents who were OW/OB (n = 86, body mass index (BMI) ≥ 85th percentile) demonstrated 5%-6%, 13%-16%, and 2.5% higher aortic and brachial systolic BP, brachial and aortic PP, and mean arterial pressure (MAP), respectively (all P < 0.05), than adolescents of normal-weight (NW, n = 141, BMI < 85th percentile). The OW/OB adolescents had a 7% higher CF-PWV, 5% lower CR-PWV, and 3.5% lower PP amplification than the NW group (all P < 0.05), but no differences in AI75 or AugP. In the entire cohort after adjustment for age, sex, heart rate, height, and MAP, CF-PWV was positively correlated, and CR-PWV and PP amplification were negatively correlated, with total and abdominal/hip adiposity. Additionally, CF-PWV, AI75, and AugP were positively correlated with MAP and negatively correlated with PP amplification. CR-PWV, AI75, and AugP were negatively correlated with brachial and aortic PP.
CONCLUSIONS
Higher aortic stiffness is associated with smaller PP amplification with increasing adiposity in African-American adolescents. Whether a reduction in PP amplification predicts increased CVD risk in obese African-American adolescents requires further study.
Details
- Title: Subtitle
- Arterial Stiffness and Pulse-Pressure Amplification in Overweight/Obese African- American Adolescents: Relation With Higher Systolic and Pulse Pressure
- Creators
- Gary L Pierce - Department of Health and Human Physiology, University of IowaHaidong Zhu - Georgia Prevention Institute, Department of Pediatrics, Georgia Health Sciences UniversityKatherine Darracott - Georgia Prevention Institute, Department of Pediatrics, Georgia Health Sciences UniversityItoro Edet - Georgia Prevention Institute, Department of Pediatrics, Georgia Health Sciences UniversityJigar Bhagatwala - Georgia Prevention Institute, Department of Pediatrics, Georgia Health Sciences UniversityYing Huang - Georgia Prevention Institute, Department of Pediatrics, Georgia Health Sciences UniversityYanbin Dong - Georgia Prevention Institute, Department of Pediatrics, Georgia Health Sciences University
- Resource Type
- Journal article
- Publication Details
- American journal of hypertension, Vol.26(1), pp.20-26
- Publisher
- Oxford University Press; US
- DOI
- 10.1093/ajh/hps014
- PMID
- 23382323
- PMCID
- PMC3626033
- ISSN
- 0895-7061
- eISSN
- 1879-1905
- Language
- English
- Date published
- 01/2013
- Academic Unit
- Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984002325902771
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