Arterial and Venous Pulmonary Vascular Morphology and Their Relationship to Findings in Cardiac Magnetic Resonance Imaging in Smokers

Farbod N Rahaghi; Carolyn E Come; J Michael Wells; Isaac A De La Bruere; Surya P Bhatt; James C Ross; Gonzalo Vegas-Sánchez-Ferrero; Alejandro A Diaz; Jasleen Minhas; Mark T Dransfield; Raúl San José Estépar; George R Washko; COPDGene Investigators

doi:10.1097/RCT.0000000000000465

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Arterial and Venous Pulmonary Vascular Morphology and Their Relationship to Findings in Cardiac Magnetic Resonance Imaging in Smokers

Journal article

Open access

Peer reviewed

Arterial and Venous Pulmonary Vascular Morphology and Their Relationship to Findings in Cardiac Magnetic Resonance Imaging in Smokers

Farbod N Rahaghi, Carolyn E Come, J Michael Wells, Isaac A De La Bruere, Surya P Bhatt, James C Ross, Gonzalo Vegas-Sánchez-Ferrero, Alejandro A Diaz, Jasleen Minhas, Mark T Dransfield, …

Journal of computer assisted tomography, Vol.40(6), pp.948-952

11/2016

DOI: 10.1097/RCT.0000000000000465

PMCID: PMC5110399

PMID: 27636250

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Abstract

Prior work has described the relationship between pulmonary vascular pruning on computed tomography (CT) scans and metrics of right-sided heart dysfunction in smokers. In this analysis, we sought to look at pruning on a lobar level, as well as examine the effect of the arterial and venous circulation on this association. Automated vessel segmentation applied to noncontrast CT scans from the COPDGene Study in 24 subjects with cardiac magnetic resonance imaging scans was used to create a blood volume distribution profile. These vessels were then manually tracked to their origin and characterized as artery or vein. Assessment of pruning on a lobar level revealed associations between pruning and right ventricular function previously not observed on a global level. The right ventricular mass index, the right ventricular end-systolic volume index, and pulmonary arterial-to-aorta ratio were associated with both arterial and venous pruning, whereas right ventricular ejection fraction was associated with only arterial pruning. Lobar assessment and segmentation of the parenchymal vasculature into arterial and venous components provide additional information about the relationship between loss of vasculature on CT scans and right ventricular dysfunction.

Pulmonary Veins - pathology

Reproducibility of Results

Prevalence

Magnetic Resonance Imaging, Cine - statistics & numerical data

Humans

Middle Aged

Risk Factors

Ventricular Dysfunction, Right - epidemiology

Male

Pulmonary Veins - diagnostic imaging

Pulmonary Artery - diagnostic imaging

Smoking - epidemiology

Sensitivity and Specificity

Multimodal Imaging - methods

Smoking - pathology

Boston - epidemiology

Female

Pulmonary Artery - pathology

Ventricular Dysfunction, Right - pathology

Ventricular Dysfunction, Right - diagnostic imaging

Details

Title: Subtitle: Arterial and Venous Pulmonary Vascular Morphology and Their Relationship to Findings in Cardiac Magnetic Resonance Imaging in Smokers
Creators: Farbod N Rahaghi - From the Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA; †Division of Pulmonary, Allergy and Critical Care Medicine, and ‡UAB Lung Health Center, University of Alabama at Birmingham; and §Birmingham VA Medical Center, Birmingham, AL; and ∥Department of Radiology Harvard School of Medicine Surgical Planning Laboratory, Boston, MA
Carolyn E Come
J Michael Wells
Isaac A De La Bruere
Surya P Bhatt
James C Ross
Gonzalo Vegas-Sánchez-Ferrero
Alejandro A Diaz
Jasleen Minhas
Mark T Dransfield
Raúl San José Estépar
George R Washko
COPDGene Investigators
Contributors: Eric A Hoffman (Contributor) - University of Iowa, Radiology
Resource Type: Journal article
Publication Details: Journal of computer assisted tomography, Vol.40(6), pp.948-952
DOI: 10.1097/RCT.0000000000000465
PMID: 27636250
PMCID: PMC5110399
NLM abbreviation: J Comput Assist Tomogr
ISSN: 0363-8715
eISSN: 1532-3145
Publisher: United States
Grant note: T32 HL007633 / NHLBI NIH HHS K01 HL118714 / NHLBI NIH HHS R01 HL116931 / NHLBI NIH HHS K08 HL123940 / NHLBI NIH HHS K23 HL114735 / NHLBI NIH HHS U01 HL089897 / NHLBI NIH HHS S10 OD018526 / NIH HHS R01 HL089897 / NHLBI NIH HHS R01 HL116473 / NHLBI NIH HHS
Language: English
Date published: 11/2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984051532602771

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