Journal article
Arterial chemoreflex in conscious normotensive and hypertensive adult rats
American journal of physiology. Heart and circulatory physiology, Vol.276(4), pp.H1215-H1222
04/01/1999
DOI: 10.1152/ajpheart.1999.276.4.H1215
PMID: 10199845
Abstract
Evidence from human and animal studies suggests that the arterial chemoreflex may be exaggerated in essential hypertension. In the present study, cardiorespiratory responses to peripheral chemoreceptor stimulation were compared in conscious unrestrained spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WKY) and Sprague-Dawley (SD) rats (13–14 wk old). Chemoreceptors were stimulated by injections of potassium cyanide (30–125 μg/kg iv). Chemoreceptor stimulation elicited a pressor response and bradycardia. The peak change in mean arterial pressure evoked during chemoreceptor stimulation was not significantly different between SH ( n= 18) and WKY ( n = 18) rats but was significantly smaller in SD rats ( n = 18). An evaluation of respiratory responses to chemoreceptor stimulation in conscious and anesthetized rats also demonstrated no significant difference between SH and WKY rats, but the response of the SD rats tended to be smaller. These results demonstrate that differences in the arterial chemoreflex response of SH vs. normotensive rats are not linked to hypertension but, rather, to differences between rat strains.
Details
- Title: Subtitle
- Arterial chemoreflex in conscious normotensive and hypertensive adult rats
- Creators
- Linda F Hayward - Cardiovascular Center and Departments of Internal Medicine, Psychology, and Pharmacology, University of Iowa, and Medical Service, Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242; and Department of Physiological Sciences, University of Florida, Gainesville, Florida 32610Alan Kim Johnson - Cardiovascular Center and Departments of Internal Medicine, Psychology, and Pharmacology, University of Iowa, and Medical Service, Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242; and Department of Physiological Sciences, University of Florida, Gainesville, Florida 32610Robert B Felder - Cardiovascular Center and Departments of Internal Medicine, Psychology, and Pharmacology, University of Iowa, and Medical Service, Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242; and Department of Physiological Sciences, University of Florida, Gainesville, Florida 32610
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.276(4), pp.H1215-H1222
- DOI
- 10.1152/ajpheart.1999.276.4.H1215
- PMID
- 10199845
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Language
- English
- Date published
- 04/01/1999
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Cardiovascular Medicine; Neuroscience and Pharmacology; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984065396402771
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