Journal article
Arterial hypertension and retinal layer thickness: the Beijing Eye Study
British journal of ophthalmology, Vol.108(1), pp.105-111
01/2024
DOI: 10.1136/bjo-2022-322229
PMID: 36428008
Abstract
PurposeTo investigate relationships between blood pressure and the thickness of single retinal layers in the macula.MethodsParticipants of the population-based Beijing Eye Study, free of retinal or optic nerve disease, underwent medical and ophthalmological examinations including optical coherence tomographic examination of the macula. Applying a multiple-surface segmentation solution, we automatically segmented the retina into its various layers.ResultsThe study included 2237 participants (mean age 61.8±8.4 years, range 50–93 years). Mean thicknesses of the retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer, inner nuclear layer (INL), outer plexiform layer, outer nuclear layer/external limiting membrane, ellipsoid zone, photoreceptor outer segments (POS) and retinal pigment epithelium–Bruch membrane were 31.1±2.3 µm, 39.7±3.5 µm, 38.4±3.3 µm, 34.8±2.0 µm, 28.1±3.0 µm, 79.2±7.3 µm, 22.9±0.6 µm, 19.2±3.3 µm and 20.7±1.4 µm, respectively. In multivariable analysis, higher systolic blood pressure (SBP) and diastolic blood pressure (DBP) were associated with thinner GCL and thicker INL, after adjusting for age, sex and axial length (all p<0.0056). Higher SBP was additionally associated with thinner POS and higher DBP with thinner RNFL. For an elevation of SBP/DBP by 10 mm Hg, the RNFL, GCL, INL and POS changed by 2.0, 3.0, 1.5 and 2.0 µm, respectively.ConclusionsThickness of RNFL, GCL and POS was inversely and INL thickness was positively associated with higher blood pressure, while the thickness of the other retinal layers was not significantly correlated with blood pressure. The findings may be helpful for refinement of the morphometric detection of retinal diseases.
Details
- Title: Subtitle
- Arterial hypertension and retinal layer thickness: the Beijing Eye Study
- Creators
- Hui Xie - University of IowaZhe Pan - Peking University Third HospitalCan Can Xue - Peking University Third HospitalDanny Chen - University of Notre DameJost B Jonas - Institute of Molecular and Clinical Ophthalmology BaselXiaodong Wu - University of IowaYa Xing Wang - Capital University
- Resource Type
- Journal article
- Publication Details
- British journal of ophthalmology, Vol.108(1), pp.105-111
- Publisher
- BMJ Publishing Group Ltd
- DOI
- 10.1136/bjo-2022-322229
- PMID
- 36428008
- ISSN
- 0007-1161
- eISSN
- 1468-2079
- Grant note
- 2019-4 / Beijing Municipal of Health Reform and Development Project 81570835 / National Natural Science Foundation of China (http://dx.doi.org/10.13039/501100001809) CCF-1733742 / National Science Foundation of USA
- Language
- English
- Electronic publication date
- 11/25/2022
- Date published
- 01/2024
- Academic Unit
- Electrical and Computer Engineering; Radiation Oncology; The Iowa Institute for Biomedical Imaging
- Record Identifier
- 9984320078802771
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