Journal article
Arterial spin labeling MRI for assessment of perfusion in native and transplanted kidneys
Magnetic resonance imaging, Vol.29(1), pp.74-82
01/01/2011
DOI: 10.1016/j.mri.2010.07.018
PMCID: PMC3005910
PMID: 20850241
Abstract
Purpose: To apply a magnetic resonance arterial spin labeling (ASL) technique to evaluate kidney perfusion in native and transplanted kidneys.
Materials and Methods: This study was compliant with the Health Insurance Portability and Accountability Act and approved by the institutional review board. Informed consent was obtained from all subjects. Renal perfusion exams were performed at 1.5 T in a total of 25 subjects: 10 with native and 15 with transplanted kidneys. A flow-sensitive alternating inversion recovery (FAIR) ASL sequence was performed with respiratory triggering in all subjects and under free-breathing conditions in five transplant subjects. Thirty-two control/tag pairs were acquired and processed using a single-compartment model. Perfusion in native and transplanted kidneys was compared above and below an estimated glomerular filtration rate (eGFR) threshold of 60 ml/min per 1.73 m(2) and correlations with eGFR were determined.
Results: In many of the transplanted kidneys, major feeding vessels in the coronal plane required a slice orientation sagittal to the kidney. Renal motion during the examination was observed in native and transplant subjects and was corrected with registration. Cortical perfusion correlated with eGFR in native (r=0.85, P=.002) and transplant subjects (r=0.61, P=.02). For subjects with eGFR >60 ml/min per 1.73 m(2), native kidneys demonstrated greater cortical (P=.01) and medullary (P=.04) perfusion than transplanted kidneys. For subjects with eGFR <60 ml/min per 1.73 m(2), native kidneys demonstrated greater medullary perfusion (P=.04) compared to transplanted kidneys. Free-breathing acquisitions provided renal perfusion measurements that were slightly lower compared to the coached/triggered technique, although no statistical differences were observed.
Conclusion: In conclusion, FAIR-ASL was able to measure renal perfusion in subjects with native and transplanted kidneys, potentially providing a clinically viable technique for monitoring kidney function. (C) 2011 Elsevier Inc. All rights reserved.
Details
- Title: Subtitle
- Arterial spin labeling MRI for assessment of perfusion in native and transplanted kidneys
- Creators
- Nathan S. Artz - University of Wisconsin–MadisonElizabeth A. Sadowski - University of Wisconsin–MadisonAndrew L. Wentland - University of Wisconsin–MadisonThomas M. Grist - University of Wisconsin–MadisonSongwon Seo - University of Wisconsin–MadisonArjang Djamali - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance imaging, Vol.29(1), pp.74-82
- DOI
- 10.1016/j.mri.2010.07.018
- PMID
- 20850241
- PMCID
- PMC3005910
- NLM abbreviation
- Magn Reson Imaging
- ISSN
- 0730-725X
- eISSN
- 1873-5894
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- R0142 DK 073680; R21 DK070243 / National Institute of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 01/01/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984274954202771
Metrics
59 Record Views