Arteriopathy of Unknown Etiology: Pathologic, Radiologic, and Cytogenetic Investigations

Malik Ghannam; Dana Ghazaleh; Azizullah Beran; Benjamin Miller; Brent Berry

doi:10.12659/AJCR.917353

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Arteriopathy of Unknown Etiology: Pathologic, Radiologic, and Cytogenetic Investigations

Journal article

Open access

Arteriopathy of Unknown Etiology: Pathologic, Radiologic, and Cytogenetic Investigations

Malik Ghannam, Dana Ghazaleh, Azizullah Beran, Benjamin Miller and Brent Berry

The American journal of case reports, Vol.20, pp.1235-1240

08/21/2019

DOI: 10.12659/AJCR.917353

PMCID: PMC6713027

PMID: 31431606

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https://doi.org/10.12659/AJCR.917353View

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Abstract

BACKGROUND Dissections occur when the intima is injured and an intramural hematoma develops between the intima and the media. There are a multitude of factors which contribute to arterial aneurysms and dissections, that could be infectious, genetic, traumatic, or environmental, but there are still cases for which the etiology is not determined. CASE REPORT We describe a patient who presented with arterial aneurysms and dissections that involved multiple vessels over the course of 10 years. We also reviewed the literature on possible risk factors, triggers, and genetic disorders that may predispose patients to developing arterial aneurysms and dissections. CONCLUSIONS To the best of our knowledge, this is the first report of this unusual pattern of presentation for idiopathic vasculopathy causing multiple dissections and aneurysms in a young patient. Idiopathic vasculopathy resulting in aneurysm and dissection is not an entirely uncommon entity; most cases of disparate dissection are not linked with a causal mechanism, although genetic influence is often heavily suspected, but it unfortunately often cannot be proven. We reviewed the available literature for a better understanding of pathologic, radiologic, and cytogenetic investigations of arteriopathy of unknown cause.

Adult

Aneurysm - complications

Aneurysm - diagnostic imaging

Aneurysm, Dissecting - complications

Aneurysm, Dissecting - diagnostic imaging

Carotid Artery Diseases - complications

Carotid Artery Diseases - diagnostic imaging

Humans

Iliac Aneurysm - complications

Iliac Aneurysm - diagnostic imaging

Magnetic Resonance Angiography

Male

Mesenteric Artery, Superior - diagnostic imaging

Details

Title: Subtitle: Arteriopathy of Unknown Etiology: Pathologic, Radiologic, and Cytogenetic Investigations
Creators: Malik Ghannam - University of Minnesota
Dana Ghazaleh - An-Najah National University
Azizullah Beran - Mayo Clinic in Arizona
Benjamin Miller - University of Minnesota
Brent Berry - University of Minnesota
Resource Type: Journal article
Publication Details: The American journal of case reports, Vol.20, pp.1235-1240
DOI: 10.12659/AJCR.917353
PMID: 31431606
PMCID: PMC6713027
NLM abbreviation: Am J Case Rep
ISSN: 1941-5923
eISSN: 1941-5923
Language: English
Date published: 08/21/2019
Academic Unit: Neurology
Record Identifier: 9984585316902771

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