Journal article
Arthritis Increases the Risk for Fractures - Results from the Women's Health Initiative
Journal of rheumatology, Vol.38(8), pp.1680-1688
08/01/2011
DOI: 10.3899/jrheum.101196
PMCID: PMC3149716
PMID: 21572148
Abstract
Objective. To examine the relationship between arthritis and fracture.
Methods. Women were classified into 3 self-reported groups at baseline: no arthritis (n = 83,295), osteoarthritis (OA; n = 63,402), and rheumatoid arthritis (RA; n = 960). Incident fractures were self-reported throughout followup. Age-adjusted fracture rates by arthritis category were generated, and the Cox proportional hazards model was used to test the association between arthritis and fracture.
Results. After an average of 7.80 years, 24,137 total fractures were reported including 2559 self-reported clinical spinal fractures and 1698 adjudicated hip fractures. For each fracture type, age-adjusted fracture rates were highest in the RA group and lowest in the nonarthritic group. After adjustment for several covariates, report of arthritis was associated with increased risk for spine, hip, and any clinical fractures. Compared to the nonarthritis group, the risk of sustaining any clinical fracture in the OA group was HR 1.09 (95% CI 1.05, 1.13; p < 0.001) and HR 1.49 (95% CI 1.26, 1.75; p <0.001) in the RA group. The risk of sustaining a hip fracture was not statistically increased in the OA group (HR 1.11; 95% CI 0.98, 1.25; p = 0.122) compared to the nonarthritis group; however, the risk of hip fracture increased significantly (HR 3.03; 95% CI 2.03, 4.51; p < 0.001) in the RA group compared to the nonarthritis group.
Conclusion. The increase in fracture risk confirms the importance of fracture prevention in patients with RA and OA. (First Release May 15 2011; J Rheumatol 2011;38:1680-8; doi:10.3899/jrheum.101196)
Details
- Title: Subtitle
- Arthritis Increases the Risk for Fractures - Results from the Women's Health Initiative
- Creators
- Nicole C. Wright - University of ArizonaJeffrey R. Lisse - University of ArizonaBrian T. Walitt - George Washington UniversityCharles B. Eaton - Brown UniversityZhao Chen - University of ArizonaWomen's Health Initiative Investigators
- Contributors
- Robert Wallace (Contributor) - University of Iowa, Internal Medicine
- Resource Type
- Journal article
- Publication Details
- Journal of rheumatology, Vol.38(8), pp.1680-1688
- DOI
- 10.3899/jrheum.101196
- PMID
- 21572148
- PMCID
- PMC3149716
- NLM abbreviation
- J Rheumatol
- ISSN
- 0315-162X
- eISSN
- 1499-2752
- Publisher
- J Rheumatol Publ Co
- Number of pages
- 9
- Grant note
- R01 AR049411-04SI / National Institute of Arthritis and Musculoskeletal and Skin Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) R21AR060811 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) N01WH022110 / WOMEN'S HEALTH INITIATIVE - OFFICE OF THE DIRECTOR NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA N01WH22110; 24152; 32100-2; 32105-6; 32108-9; 32111-13; 32115; 32118-32119; 32122; 42107-26; 42129-32; 44221 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 08/01/2011
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363613802771
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