Journal article
Asbestos-induced Pleural Fibrosis and Impaired Lung function
The American review of respiratory disease, Vol.141(2), pp.321-326
02/1990
DOI: 10.1164/ajrccm/141.2.321
PMID: 2301850
Abstract
To assess the clinical significance of asbestos-induced pleural fibrosis, we evaluated the relationship between radiographic evidence of pleural fibrosis and spirometric values in 1,211 sheet metal workers. Of those with pleural fibrosis (n = 334), 78% had circumscribed plaques and 22% had diffuse pleural thickening involving the costophrenic angle. Factors that were found to be associated with the presence and type of pleural fibrosis included increased age (p < 0.001), more years in the trade (p < 0.0001), more years since first exposure to asbestos (p < 0.0001), more pack-years of cigarette smoking (p < 0.01), and the presence and degree of interstitial fibrosis (p < 0.0001). After controlling for these potential confounders (age, years in the trade, latency, pack-years of smoking, and ILO profusion category), linear multivariate regression models demonstrated that both circumscribed plaques (p = 0.007) and diffuse pleural thickening (p = 0.008) were independently associated with decrements in FVC but not with decrements in the FEV1/FVC ratio. Furthermore, our data indicate that the effect of diffuse pleural thickening on decrements in FVC is approximately twice as great as that seen with circumscribed pleural plaques. We conclude that the presence and type of pleural fibrosis among asbestos-exposed workers is independently associated with a pattern of spirometry that is suggestive of an underlying restrictive defect in lung function.
Details
- Title: Subtitle
- Asbestos-induced Pleural Fibrosis and Impaired Lung function
- Creators
- David A. Schwartz - University of IowaLaurence J. Fuortes - University of IowaJeffrey R. Galvin - University of IowaLeon F. Burmeister - University of IowaLynn E. Schmidt - University of IowaBruce N. Leistikow - University of IowaFrank P. Lamarte - University of IowaJames A. Merchant - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The American review of respiratory disease, Vol.141(2), pp.321-326
- DOI
- 10.1164/ajrccm/141.2.321
- PMID
- 2301850
- ISSN
- 0003-0805
- eISSN
- 2376-3752
- Language
- English
- Date published
- 02/1990
- Academic Unit
- Occupational and Environmental Health; Internal Medicine
- Record Identifier
- 9984363586602771
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