Journal article
Ascertainment of vaccination status by self-report versus source documentation: Impact on measuring COVID-19 vaccine effectiveness
Influenza and other respiratory viruses, Vol.16(6), pp.1101-1111
07/11/2022
DOI: 10.1111/irv.13023
PMCID: PMC9350035
PMID: 35818721
Abstract
Background
During the COVID-19 pandemic, self-reported COVID-19 vaccination might facilitate rapid evaluations of vaccine effectiveness (VE) when source documentation (e.g., immunization information systems [IIS]) is not readily available. We evaluated the concordance of COVID-19 vaccination status ascertained by self-report versus source documentation and its impact on VE estimates.
Methods
Hospitalized adults (≥18 years) admitted to 18 U.S. medical centers March–June 2021 were enrolled, including COVID-19 cases and SARS-CoV-2 negative controls. Patients were interviewed about COVID-19 vaccination. Abstractors simultaneously searched IIS, medical records, and other sources for vaccination information. To compare vaccination status by self-report and documentation, we estimated percent agreement and unweighted kappa with 95% confidence intervals (CIs). We then calculated VE in preventing COVID-19 hospitalization of full vaccination (2 doses of mRNA product ≥14 days prior to illness onset) independently using data from self-report or source documentation.
Results
Of 2520 patients, 594 (24%) did not have self-reported vaccination information to assign vaccination group; these patients tended to be more severely ill. Among 1924 patients with both self-report and source documentation information, 95.0% (95% CI: 93.9–95.9%) agreement was observed, with a kappa of 0.9127 (95% CI: 0.9109–0.9145). VE was 86% (95% CI: 81–90%) by self-report data only and 85% (95% CI: 81-89%) by source documentation data only.
Conclusions
Approximately one-quarter of hospitalized patients could not provide self-report COVID-19 vaccination status. Among patients with self-report information, there was high concordance with source documented status. Self-report may be a reasonable source of COVID-19 vaccination information for timely VE assessment for public health action.
Details
- Title: Subtitle
- Ascertainment of vaccination status by self-report versus source documentation: Impact on measuring COVID-19 vaccine effectiveness
- Creators
- Meagan StephensonSamantha M OlsonWesley H SelfAdit A GindeNicholas M MohrManjusha GaglaniNathan I ShapiroKevin W GibbsDavid N HagerMatthew E PrekkerMichelle N GongJay S SteingrubIthan D PeltanEmily T MartinRaju ReddyLaurence W BusseAbhijit DuggalJennifer G WilsonNida QadirChristopher MallowJennie H KwonMatthew C ExlineJames D ChappellAdam S LauringAdrienne BaughmanChristopher J LindsellKimberly W HartNathaniel M LewisManish M PatelMark W Tenforde
- Resource Type
- Journal article
- Publication Details
- Influenza and other respiratory viruses, Vol.16(6), pp.1101-1111
- DOI
- 10.1111/irv.13023
- PMID
- 35818721
- PMCID
- PMC9350035
- NLM abbreviation
- Influenza Other Respir Viruses
- ISSN
- 1750-2640
- eISSN
- 1750-2659
- Grant note
- DOI: 10.13039/100015096, name: Canadian Dairy Commission; DOI: 10.13039/100006108, name: National Center for Advancing Translational Sciences, award: UL1 TR002243; DOI: 10.13039/100000030, name: Centers for Disease Control and Prevention, award: 75D30121F00002
- Language
- English
- Date published
- 07/11/2022
- Academic Unit
- Epidemiology; Emergency Medicine; Anesthesia; Injury Prevention Research Center
- Record Identifier
- 9984296994602771
Metrics
19 Record Views