Journal article
Ascorbate Autoxidation in the Presence of Iron and Copper Chelates
Free radical research, Vol.1(6), pp.349-353
1986
DOI: 10.3109/10715768609051638
PMID: 2851502
Abstract
Chelates can inhibit the iron- and copper-catalyzed autoxidation of ascorbate at pH 7.0. Diethylenetri-aminepentaacetic acid (DTPA or DETAPAC) and Desferal (deferoximane mesylate) slow the iron-catalyzed oxidation of ascorbate as effectively as reducing the trace levels of contaminating iron in buffers with Chelex resin. DETAPAC, EDTA and HEDTA (N-(2-hydroxyethyl)-ethylenediaminetriacetic acid) are effective at slowing the copper-catalyzed autoxidation of ascorbate while Desferal is ineffective. The ability to inhibit ascorbate autoxidation appears to parallel the rate of the reaction of superoxide with the iron chelate.
Details
- Title: Subtitle
- Ascorbate Autoxidation in the Presence of Iron and Copper Chelates
- Creators
- Garry R Buettner - 1GSF (Gesellschaft für Strahlen- und Umweltforschung) Abteilung für Strahlenbiologie, D-8042, Neuherberg, FRGProf. G Czapski - 1GSF (Gesellschaft für Strahlen- und Umweltforschung) Abteilung für Strahlenbiologie, D-8042, Neuherberg, FRG
- Resource Type
- Journal article
- Publication Details
- Free radical research, Vol.1(6), pp.349-353
- Publisher
- Informa UK Ltd
- DOI
- 10.3109/10715768609051638
- PMID
- 2851502
- ISSN
- 1071-5762
- eISSN
- 1029-2470
- Language
- English
- Date published
- 1986
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984047981002771
Metrics
23 Record Views