Journal article
Ascorbate induces autophagy in pancreatic cancer
Autophagy, Vol.6(3), pp.421-422
04/01/2010
DOI: 10.4161/auto.6.3.11527
PMCID: PMC2859094
PMID: 20400857
Abstract
Ascorbate (ascorbic acid, vitamin C) is one of the early, unorthodox treatments for cancer. The evidence upon which people base the use of ascorbate in cancer treatment falls into two categories: clinical data on dose concentration relationships, and laboratory data describing potential cell toxicity with high concentrations of ascorbate in vitro. Clinical data show that when ascorbate is given orally, fasting plasma concentrations are tightly controlled by decreased absorption, increased urine excretion, and reduced ascorbate bioavailability. In contrast, when ascorbate is administered intravenously, concentrations in the millimolar level are achieved. Thus, it is clear that intravenous administration of ascorbate can yield very high plasma levels, while oral treatment does not.
Details
- Title: Subtitle
- Ascorbate induces autophagy in pancreatic cancer
- Creators
- Joseph J. Cullen - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Autophagy, Vol.6(3), pp.421-422
- DOI
- 10.4161/auto.6.3.11527
- PMID
- 20400857
- PMCID
- PMC2859094
- NLM abbreviation
- Autophagy
- ISSN
- 1554-8627
- eISSN
- 1554-8635
- Publisher
- Landes Bioscience
- Number of pages
- 2
- Grant note
- R21 CA115785-01A1; CA115785; R21 CA115785-02; R21 CA115785 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R21CA115785 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) I01BX001318 / Veterans Affairs; US Department of Veterans Affairs I01 BX001318 / BLRD VA
- Language
- English
- Date published
- 04/01/2010
- Academic Unit
- Surgery; Radiation Oncology
- Record Identifier
- 9984312985202771
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