Journal article
Asian Americans and prostate cancer: A nationwide population-based analysis
Urologic oncology, Vol.34(5), pp.233.e7-233.e15
05/01/2016
DOI: 10.1016/j.urolonc.2015.11.013
PMID: 26725248
Abstract
It remains largely unknown if there are racial disparities in outcomes of prostate cancer (PCa) for Asian American and Pacific Islanders (PIs) (AAPIs). We examined differences in diagnosis, management, and survival of AAPI ethnic groups, relative to their non-Hispanic White (NHW) counterparts.
Patients (n = 891,100) with PCa diagnosed between 1988 and 2010 within the surveillance, epidemiology, and end results database were extracted and stratified by ethnic group: Chinese, Japanese, Filipino, Hawaiian, Korean, Vietnamese, Asian Indian/Pakistani, PI, and Other Asian. The effect of ethnic group on stage at presentation, rates of definitive treatment, and PCa-specific mortality was assessed. The severity at diagnosis was defined as: localized (TxN0M0), regional (TxN1M0), or metastatic (TxNxM1).
Relative to NHWs, Asian Indian/Pakistani, Filipino, Hawaiian, and PI men had significantly worse outcomes. Filipino (odds ratio [OR] = 1.38, 95% CI: 1.27–1.51), Hawaiian, (OR = 1.70, 95% CI: 1.41–2.04), Asian Indian/Pakistani (OR = 1.37, 95% CI: 1.15–1.64), and PI men (OR = 1.90, 95% CI: 1.46–2.49) were more likely to present with metastatic PCa (P<0.001). In patients with localized PCa, Filipino men were less likely to receive definitive treatment (OR = 0.91; 95% CI: 0.84–0.97; P = 0.005). Most AAPI groups had lower rates of PCa death except for Hawaiian (hazard ratio = 1.52; 95% CI: 1.30–1.77; P<0.0001) and PI men (hazard ratio = 1.43; 95% CI: 1.12–1.82; P<0.0001).
Compared with NHWs, AAPI groups were more likely to present with advanced PCa but had better cancer-specific survival. Conversely, Hawaiian and PI men were at greater risk for PCa-specific mortality. Given the different cancer profiles, our results show that there is a need for disaggregation of AAPI data.
•SEER data between 1988 and 2010 from patients with prostate cancer were extracted and stratified by ethic groups.•Most Asian Americans/Pacific Islanders groups had lower rates of prostate cancer death except for Hawaiian and Pacific Islanders.•Compared with non-Hispanic Whites, Asian Americans/Pacific Islanders were more likely to present advanced prostate cancer.•These groups showed a better cancer-specific survival.
Details
- Title: Subtitle
- Asian Americans and prostate cancer: A nationwide population-based analysis
- Creators
- Grace F. Chao - Harvard UniversityNandita Krishna - Brigham and Women's HospitalAyal A. Aizer - Brigham and Women's HospitalDeepansh Dalela - Henry Ford Health SystemJulian Hanske - Brigham and Women's HospitalHanhan Li - Henry Ford Health SystemChristian P. Meyer - Brigham and Women's HospitalSimon P. Kim - Case Western Reserve UniversityBrandon A. Mahal - Harvard UniversityGally Reznor - Harvard UniversityMarianne Schmid - Brigham and Women's HospitalToni K. Choueiri - Dana-Farber Cancer InstitutePaul L. Nguyen - Dana-Farber Cancer InstituteMichael O׳Leary - Harvard Medical SchoolQuoc-Dien Trinh - Harvard Medical School
- Resource Type
- Journal article
- Publication Details
- Urologic oncology, Vol.34(5), pp.233.e7-233.e15
- DOI
- 10.1016/j.urolonc.2015.11.013
- PMID
- 26725248
- NLM abbreviation
- Urol Oncol
- ISSN
- 1078-1439
- eISSN
- 1873-2496
- Publisher
- Elsevier Inc
- Grant note
- Harvard Medical School, United States
- Language
- English
- Date published
- 05/01/2016
- Academic Unit
- Urology
- Record Identifier
- 9984949470302771
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