Journal article
Aspartame-sweetened beverage: effect on plasma amino acid concentrations in normal adults and adults heterozygous for phenylketonuria
The Journal of nutrition, Vol.117(11), pp.1989-1995
1987
DOI: 10.1093/jn/117.11.1989
PMID: 2890728
Abstract
Twelve normal subjects ingested either unsweetened beverage (n = 6) or beverage providing 4 mg/kg body weight as aspartame (APM) (n = 6). Neither beverage had any significant effect on plasma aspartate or phenylalanine concentrations. After this study, eight normal and six obligate phenylketonuric (PKU) heterozygous adults each ingested a 354-mL (12-oz) beverage serving on two occasions in a randomized cross-over design. On one occasion the beverage was not sweetened; on the other occasion, the beverage provided 10 mg APM/kg body weight. Plasma amino acid concentrations were measured throughout the 2-h study period. The addition of 10 mg APM/kg body weight to the beverage had no significant effect on plasma aspartate concentration. APM ingestion increased plasma phenylalanine levels of normal subjects from a mean ± SD baseline value of 5.09 ± 0.82 µmol/dL to a high mean value of 6.73 ± 0.75 µmol/dL. In PKU heterozygous subjects the plasma phenylalanine level increased from a mean ± SD of 9.04 ± 1.71 to a high mean value of 12.1 ± 2.08 µmol/dL. The data indicate ready metabolism of the aspartate and phenylalanine portion of APM when administered at levels likely to be ingested by individuals who drink diet beverages.
Details
- Title: Subtitle
- Aspartame-sweetened beverage: effect on plasma amino acid concentrations in normal adults and adults heterozygous for phenylketonuria
- Creators
- L. D STEGINK - Univ. Iowa coll. medicine, dep. pediatrics, Iowa city IA 52242, United StatesL. C WOLF-NOVAK - Univ. Iowa coll. medicine, dep. pediatrics, Iowa city IA 52242, United StatesL. J Filer Jr - Univ. Iowa coll. medicine, dep. pediatrics, Iowa city IA 52242, United StatesE. F BELL - Univ. Iowa coll. medicine, dep. pediatrics, Iowa city IA 52242, United StatesE. E ZIEGLER - Univ. Iowa coll. medicine, dep. pediatrics, Iowa city IA 52242, United StatesW. L KRAUSE - Univ. Iowa coll. medicine, dep. pediatrics, Iowa city IA 52242, United StatesM. C BRUMMEL - Univ. Iowa coll. medicine, dep. pediatrics, Iowa city IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- The Journal of nutrition, Vol.117(11), pp.1989-1995
- Publisher
- American Society for Nutritional Sciences
- DOI
- 10.1093/jn/117.11.1989
- PMID
- 2890728
- ISSN
- 0022-3166
- eISSN
- 1541-6100
- Language
- English
- Date published
- 1987
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984093364302771
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