Journal article
Aspects of the production of 18F-2-deoxy-2-fluoro-d-glucose via 18F2 with a Tandem Van de Graaf accelerator
The International journal of applied radiation and isotopes, Vol.32(1), pp.23-29
01/1981
DOI: 10.1016/0020-708X(81)90173-3
Abstract
During deuteron irradiation of 100 psig neon containing 1-2% of elemental fluorine, the induced 18F partitions into three main fractions. About 50% remains in the passivated nickel target after elution of the gas mixture. Some of the gaseous 18F is capable of performing fluorination reactions and is presumed to be 18F2; the rest is a mixture of at least two unreactive gases, one of which behaves on gas chromatography like CF4. The ratio of reactive to unreactive gaseous 18F decreases with longer irradiation times but increases when the target gas is cooled to -30°C during bombardment. Reaction of the presumed 18F2 with 4,5,6-triacetyl-d-glucal, essentially by the published method, yielded 18F-2-deoxy-2-fluoro-4,5,6-triacetyl-α-d-glucosyl fluoride and the corresponding β-d-mannosyl fluoride. These were separated either by column chromatography or preparative TLC, using plates with a pre-absorbent layer. Hydrolysis of the glucosyl fluoride gave 18F-2-deoxy-2-fluoro-d-glucose (18F-2FDG) with a decay-corrected yield of about 10%, based on 18F trapped by the triacetylglucal. The 60 min organ distribution of 18F from 18F-2FDG in tumor bearing rats was compared with the corresponding distribution after administration of 18F-3-deoxy-3-fluoro-d-glucose (18F-3FDG). Organ/ blood ratios were uniformly higher for 18F-2FDG than for no carrier added 18F-3FDG; only heart, brain and thyroid had ratios greater than unity. Added carrier 3-FDG further lowered organ/blood ratios. The main conclusion drawn from this animal work is that 18F-3FDG is unlikely to rival 18F-2FDG for nuclear medicine studies, where high target/blood ratios (obtained by metabolic trapping as the sugar-6-phosphate) are necessary. However, 18F-3FDG may be useful for estimating the concentration of free glucose in organs if further work confirms that it is an essentially non-metabolized analog of glucose. © 1981.
Details
- Title: Subtitle
- Aspects of the production of 18F-2-deoxy-2-fluoro-d-glucose via 18F2 with a Tandem Van de Graaf accelerator
- Creators
- W.J ShaugnessyS.J GatleyR.D HichwaL.M LiebermanR.J Nickles
- Resource Type
- Journal article
- Publication Details
- The International journal of applied radiation and isotopes, Vol.32(1), pp.23-29
- DOI
- 10.1016/0020-708X(81)90173-3
- ISSN
- 0020-708X
- Language
- English
- Date published
- 01/1981
- Academic Unit
- Physics and Astronomy; Research Administration; Radiology; Radiation Oncology
- Record Identifier
- 9984213293102771
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