Journal article
Asphyxia, Therapeutic Hypothermia, and Pulmonary Hypertension
Clinics in perinatology, Vol.51(1), pp.127-149
03/2024
DOI: 10.1016/j.clp.2023.11.007
Abstract
Neonates with a perinatal hypoxic insult and subsequent neonatal encephalopathy are at risk of acute pulmonary hypertension (aPH) in the transitional period. The phenotypic contributors to aPH following perinatal asphyxia include a combination of hypoxic vasoconstriction of the pulmonary vascular bed, right heart dysfunction, and left heart dysfunction. Therapeutic hypothermia is the standard of care for neonates with moderate-to-severe hypoxic ischemic encephalopathy. This review summarizes the underlying risk factors, causes of aPH in neonates with perinatal asphyxia, discusses the unique phenotypical contributors to disease, and explores the impact of the initial insult and subsequent therapeutic hypothermia on aPH.
Details
- Title: Subtitle
- Asphyxia, Therapeutic Hypothermia, and Pulmonary Hypertension
- Creators
- Regan GeisingerDanielle R. RiosPatrick J. McNamaraPhilip T. Levy
- Resource Type
- Journal article
- Publication Details
- Clinics in perinatology, Vol.51(1), pp.127-149
- DOI
- 10.1016/j.clp.2023.11.007
- ISSN
- 0095-5108
- eISSN
- 1557-9840
- Language
- English
- Electronic publication date
- 12/2023
- Date published
- 03/2024
- Academic Unit
- Stead Family Department of Pediatrics; Internal Medicine; Neonatology
- Record Identifier
- 9984539438602771
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