Aspirin and other nonsteroidal anti-inflammatory drugs, statins and risk of non-Hodgkin lymphoma

Mark Liebow; Melissa C Larson; Carrie A Thompson; Grzegorz S Nowakowski; Timothy G Call; William R Macon; Neil E Kay; Thomas M Habermann; Susan L Slager; James R Cerhan

doi:10.1002/ijc.33541

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Aspirin and other nonsteroidal anti-inflammatory drugs, statins and risk of non-Hodgkin lymphoma

Journal article

Open access

Peer reviewed

Aspirin and other nonsteroidal anti-inflammatory drugs, statins and risk of non-Hodgkin lymphoma

Mark Liebow, Melissa C Larson, Carrie A Thompson, Grzegorz S Nowakowski, Timothy G Call, William R Macon, Neil E Kay, Thomas M Habermann, Susan L Slager and James R Cerhan

International journal of cancer, Vol.149(3), pp.535-545

08/01/2021

DOI: 10.1002/ijc.33541

PMCID: PMC8192479

PMID: 33644854

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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) and statin drugs may protect against the development of non-Hodgkin lymphoma (NHL), but data are limited, particularly for NHL subtypes. Furthermore, some in vitro, animal and epidemiologic data suggest there may be a synergistic effect of these two agents, but there has been no test of this hypothesis in NHL. We evaluated the self-reported use of NSAIDs and statins in a clinic-based study of 1703 NHL patients and 2199 frequency-matched controls. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for potential confounding variables. We observed an inverse association of regular use of low-dose aspirin with risk of NHL (OR = 0.82; 95% CI 0.70-0.96) that was stronger with longer duration of use (P < .01). There were no associations for use of regular or extra-strength aspirin, ibuprofen, other NSAIDs, statins or other cholesterol-lowering drugs with NHL risk, while an inverse association with COX-2 inhibitors was equivocal. There was also no interaction of low-dose aspirin and statins on NHL risk. Inverse associations of similar magnitude to all NHL were observed for regular use of low-dose aspirin with diffuse large B-cell, follicular, marginal zone and all other lymphomas, although not all associations were statistically significant. In conclusion, low-dose aspirin but not regular/extra strength aspirin, other NSAIDs or statin use was associated with lower risk of NHL. Beyond the potential for the primary prevention of NHL, these data also point to a role of anti-platelet or other effects of low-dose aspirin in lymphomagenesis that warrant follow-up.

Adult

Aged

Alcohol Drinking - adverse effects

Anti-Inflammatory Agents, Non-Steroidal - adverse effects

Aspirin - adverse effects

Female

Follow-Up Studies

Humans

Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects

Incidence

Lymphoma, Non-Hodgkin - epidemiology

Lymphoma, Non-Hodgkin - etiology

Lymphoma, Non-Hodgkin - pathology

Male

Middle Aged

Prognosis

Prospective Studies

Risk Factors

United States - epidemiology

Details

Title: Subtitle: Aspirin and other nonsteroidal anti-inflammatory drugs, statins and risk of non-Hodgkin lymphoma
Creators: Mark Liebow - Mayo Clinic
Melissa C Larson - Mayo Clinic
Carrie A Thompson - Mayo Clinic
Grzegorz S Nowakowski - Mayo Clinic
Timothy G Call - Mayo Clinic
William R Macon - Mayo Clinic
Neil E Kay - Mayo Clinic
Thomas M Habermann - Mayo Clinic
Susan L Slager - Mayo Clinic
James R Cerhan - Division of Epidemiology Department of Health Sciences Research, Mayo Clinic Rochester Minnesota USA
Resource Type: Journal article
Publication Details: International journal of cancer, Vol.149(3), pp.535-545
DOI: 10.1002/ijc.33541
PMID: 33644854
PMCID: PMC8192479
ISSN: 0020-7136
eISSN: 1097-0215
Grant note: R01 CA092153 / NCI NIH HHS P30 CA015083 / NCI NIH HHS P50 CA097274 / NCI NIH HHS
Language: English
Date published: 08/01/2021
Academic Unit: Epidemiology
Record Identifier: 9984368085802771

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