Journal article
Aspirin as a promising agent for decreasing incidence of cerebral aneurysm rupture
Stroke (1970), Vol.42(11), pp.3156-3162
11/2011
DOI: 10.1161/STROKEAHA.111.619411
PMCID: PMC3432499
PMID: 21980208
Abstract
Chronic inflammation is postulated as an important phenomenon in intracranial aneurysm wall pathophysiology. This study was conducted to determine if aspirin use impacts the occurrence of intracranial aneurysm rupture.
Subjects enrolled in the International Study of Unruptured Intracranial Aneurysms (ISUIA) were selected from the prospective untreated cohort (n=1691) in a nested case-control study. Cases were subjects who subsequently had a proven aneurysmal subarachnoid hemorrhage during a 5-year follow-up period. Four control subjects were matched to each case by site and size of aneurysm (58 cases, 213 control subjects). Frequency of aspirin use was determined at baseline interview. Aspirin frequency groups were analyzed for risk of aneurysmal hemorrhage. Bivariable and multivariable analyses were performed using conditional logistic regression.
A trend of a protective effect for risk of unruptured intracranial aneurysm rupture was observed. Patients who used aspirin 3× weekly to daily had an OR for hemorrhage of 0.40 (95% CI, 0.18-0.87); reference group, no use of aspirin), patients in the "< once a month" group had an OR of 0.80 (95% CI, 0.31-2.05), and patients in the "> once a month to 2×/week" group had an OR of 0.87 (95% CI, 0.27-2.81; P=0.025). In multivariable risk factor analyses, patients who used aspirin 3 times weekly to daily had a significantly lower odds of hemorrhage (adjusted OR, 0.27; 95% CI, 0.11-0.67; P=0.03) compared with those who never take aspirin.
Frequent aspirin use may confer a protective effect for risk of intracranial aneurysm rupture. Future investigation in animal models and clinical studies is needed.
Details
- Title: Subtitle
- Aspirin as a promising agent for decreasing incidence of cerebral aneurysm rupture
- Creators
- David M Hasan - Department of Neurosurgery, Carver College of Medicine, University of Iowa, Iowa City, USAKelly B MahaneyRobert D Brown JrIrene MeissnerDavid G PiepgrasJohn HustonAna W CapuanoJames C TornerInternational Study of Unruptured Intracranial Aneurysms Investigators
- Resource Type
- Journal article
- Publication Details
- Stroke (1970), Vol.42(11), pp.3156-3162
- DOI
- 10.1161/STROKEAHA.111.619411
- PMID
- 21980208
- PMCID
- PMC3432499
- NLM abbreviation
- Stroke
- ISSN
- 0039-2499
- eISSN
- 1524-4628
- Publisher
- United States
- Grant note
- RC1 NS068092 / NINDS NIH HHS R01 NS028492 / NINDS NIH HHS R01-NS-28492 / NINDS NIH HHS 1RC1-NS068092-01 / NINDS NIH HHS R01 NS048597 / NINDS NIH HHS
- Language
- English
- Date published
- 11/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery; Otolaryngology
- Record Identifier
- 9983996196902771
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