Journal article
Aspirin associated with decreased rate of intracranial aneurysm growth
Journal of neurosurgery, Vol.133(5), pp.1478-1485
11/2020
DOI: 10.3171/2019.6.JNS191273
PMID: 31662579
Abstract
OBJECTIVEAspirin has emerged as a potential agent in the prevention of rupture of intracranial aneurysms (IAs). In this study, the authors’ goal was to test if aspirin is protective against aneurysm growth in patients harboring multiple IAs ≤ 5 mm.METHODSThe authors performed a retrospective review of a prospectively maintained database covering the period July 2009 through January 2019. Patients’ data were included if the following criteria were met: 1) the patient harbored multiple IAs; 2) designated primary aneurysms were treated by surgical/endovascular means; 3) the remaining aneurysms were observed for growth; and 4) a follow-up period of at least 5 years after the initial treatment was available. Demographics, earlier medical history, the rupture status of designated primary aneurysms, aneurysms’ angiographic features, and treatment modalities were gathered.RESULTSThe authors identified 146 patients harboring a total of 375 IAs. At the initial encounter, 146 aneurysms were treated and the remaining 229 aneurysms (2–5 mm) were observed. During the follow-up period, 24 (10.48%) of 229 aneurysms grew. All aneurysms observed to grow later underwent treatment. None of the observed aneurysms ruptured. Multivariate analysis showed that aspirin was significantly associated with a decreased rate of growth (odds ratio [OR] 0.19, 95% confidence interval [CI] 0.05–0.63). Variables associated with an increased rate of growth included hypertension (OR 14.38, 95% CI 3.83–53.94), drug abuse (OR 11.26, 95% CI 1.21–104.65), history of polycystic kidney disease (OR 9.48, 95% CI 1.51–59.35), and subarachnoid hemorrhage at presentation (OR 5.91, 95% CI 1.83–19.09).CONCLUSIONSIn patients with multiple IAs, aspirin significantly decreased the rate of aneurysm growth over time. Additional prospective interventional studies are needed to validate these findings.
Details
- Title: Subtitle
- Aspirin associated with decreased rate of intracranial aneurysm growth
- Creators
- Mario Zanaty - Departments of 1NeurosurgeryJorge A Roa - Departments of 1Neurosurgery,, 2NeurologyDaichi Nakagawa - 3Department of Neurosurgery, The University of Tokyo Hospital, Tokyo, JapanNohra Chalouhi - 4Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania; andLauren Allan - 5SurgerySami Al Kasab - 2NeurologyKaustubh Limaye - 2NeurologyDaizo Ishii - 6Department of Neurosurgery, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, JapanEdgar A Samaniego - Departments of 1Neurosurgery,, 2Neurology,, 7Radiology, andPascal Jabbour - 4Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania; andJames C Torner - 8Epidemiology and Public Health, University of Iowa Hospitals and Clinics, Iowa City, IowaDavid M Hasan - Departments of 1Neurosurgery
- Resource Type
- Journal article
- Publication Details
- Journal of neurosurgery, Vol.133(5), pp.1478-1485
- DOI
- 10.3171/2019.6.JNS191273
- PMID
- 31662579
- NLM abbreviation
- J Neurosurg
- ISSN
- 0022-3085
- eISSN
- 1933-0693
- Language
- English
- Date published
- 11/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Epidemiology; Iowa Neuroscience Institute; Surgery; Injury Prevention Research Center; Neurosurgery; Otolaryngology
- Record Identifier
- 9984070641702771
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