Assessing Behavioural Manifestations Prior to Clinical Diagnosis of Huntington Disease: "Anger and Irritability" and "Obsessions and Compulsions"

Anthony L Vaccarino; Terrence Sills; Karen E. Anderson; Beth Borowsky; Emil Coccaro; David Craufurd; Jean Endicott; Joseph Giuliano; Mark Groves; Mark Guttman; Aileen K Ho; Peter Kupchak; Jane S. Paulsen; Matthew S. Stanford; Daniel P van Kammen; David Watson; Kevin D Wu; Ken Evans

doi:10.1371/currents.RRN1241

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Assessing Behavioural Manifestations Prior to Clinical Diagnosis of Huntington Disease: "Anger and Irritability" and "Obsessions and Compulsions"

Journal article

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Assessing Behavioural Manifestations Prior to Clinical Diagnosis of Huntington Disease: "Anger and Irritability" and "Obsessions and Compulsions"

Anthony L Vaccarino, Terrence Sills, Karen E. Anderson, Beth Borowsky, Emil Coccaro, David Craufurd, Jean Endicott, Joseph Giuliano, Mark Groves, Mark Guttman, …

PLoS currents, Vol.3, pp.RRN1241-RRN1241

07/11/2011

DOI: 10.1371/currents.RRN1241

PMCID: PMC3122583

PMID: 21826116

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Abstract

The Functional Rating Scale Taskforce for pre-Huntington Disease (FuRST-pHD) is a multinational, multidisciplinary initiative with the goal of developing a data-driven, comprehensive, psychometrically sound, rating scale for assessing symptoms and functional ability in prodromal and early Huntington disease (HD) gene expansion carriers. The process involves input from numerous sources to identify relevant symptom domains, including HD individuals, caregivers, and experts from a variety of fields, as well as knowledge gained from the analysis of data from ongoing large-scale studies in HD using existing clinical scales. This is an iterative process in which an ongoing series of field tests in prodromal (prHD) and early HD individuals provides the team with data on which to make decisions regarding which questions should undergo further development or testing and which should be excluded. We report here the development and assessment of the first iteration of interview questions aimed to assess "Anger and Irritability" and "Obsessions and Compulsions" in prHD individuals.

Huntington Disease

Details

Title: Subtitle: Assessing Behavioural Manifestations Prior to Clinical Diagnosis of Huntington Disease: "Anger and Irritability" and "Obsessions and Compulsions"
Creators: Anthony L Vaccarino - Research Methods, Ontario Cancer Biomarker Network, Toronto, Ontario, Canada
Terrence Sills - Ovarian Cancer Canada
Karen E. Anderson
Beth Borowsky - CHDI Foundation
Emil Coccaro - Research Psychiatrist, New York, NY
David Craufurd - University of Manchester
Jean Endicott - Columbia University
Joseph Giuliano - CHDI Foundation
Mark Groves - Mount Sinai Beth Israel
Mark Guttman - University of Toronto
Aileen K Ho - University of Reading
Peter Kupchak - Research Methods, Ontario Cancer Biomarker Network, Toronto, Ontario, Canada
Jane S. Paulsen - University of Iowa
Matthew S. Stanford - Baylor University
Daniel P van Kammen - International Drug Development
David Watson
Kevin D Wu
Ken Evans
Resource Type: Journal article
Publication Details: PLoS currents, Vol.3, pp.RRN1241-RRN1241
Publisher: Public Library of Science
DOI: 10.1371/currents.RRN1241
PMID: 21826116
PMCID: PMC3122583
ISSN: 2157-3999
eISSN: 2157-3999
Language: English
Date published: 07/11/2011
Academic Unit: Psychiatry; Psychological and Brain Sciences
Record Identifier: 9984383315102771

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