Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association

Heinrich Taegtmeyer; Martin E Young; Gary D Lopaschuk; E Dale Abel; Henri Brunengraber; Victor Darley-Usmar; Christine Des Rosiers; Robert Gerszten; Jan F Glatz; Julian L Griffin; Robert J Gropler; Hermann-Georg Holzhuetter; Jorge R Kizer; E Douglas Lewandowski; Craig R Malloy; Stefan Neubauer; Linda R Peterson; Michael A Portman; Fabio A Recchia; Jennifer E Van Eyk; Thomas J Wang

doi:10.1161/RES.0000000000000097

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Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association

Journal article

Open access

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Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association

Heinrich Taegtmeyer, Martin E Young, Gary D Lopaschuk, E Dale Abel, Henri Brunengraber, Victor Darley-Usmar, Christine Des Rosiers, Robert Gerszten, Jan F Glatz, Julian L Griffin, …

Circulation research, Vol.118(10), pp.1659-U485

05/13/2016

DOI: 10.1161/RES.0000000000000097

PMCID: PMC5130157

PMID: 27012580

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Abstract

In a complex system of interrelated reactions, the heart converts chemical energy to mechanical energy. Energy transfer is achieved through coordinated activation of enzymes, ion channels, and contractile elements, as well as structural and membrane proteins. The heart's needs for energy are difficult to overestimate. At a time when the cardiovascular research community is discovering a plethora of new molecular methods to assess cardiac metabolism, the methods remain scattered in the literature. The present statement on "Assessing Cardiac Metabolism" seeks to provide a collective and curated resource on methods and models used to investigate established and emerging aspects of cardiac metabolism. Some of those methods are refinements of classic biochemical tools, whereas most others are recent additions from the powerful tools of molecular biology. The aim of this statement is to be useful to many and to do justice to a dynamic field of great complexity.

American Heart Association

Computational Biology - methods

Animals

Cardiovascular Diseases - metabolism

United States

Humans

Myocardium - metabolism

Cardiovascular Diseases - diagnostic imaging

Cardiac Imaging Techniques - methods

Cardiovascular Diseases - genetics

Details

Title: Subtitle: Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association
Creators: Heinrich Taegtmeyer
Martin E Young
Gary D Lopaschuk
E Dale Abel
Henri Brunengraber
Victor Darley-Usmar
Christine Des Rosiers
Robert Gerszten
Jan F Glatz
Julian L Griffin
Robert J Gropler
Hermann-Georg Holzhuetter
Jorge R Kizer
E Douglas Lewandowski
Craig R Malloy
Stefan Neubauer
Linda R Peterson
Michael A Portman
Fabio A Recchia
Jennifer E Van Eyk
Thomas J Wang
Resource Type: Journal article
Publication Details: Circulation research, Vol.118(10), pp.1659-U485
DOI: 10.1161/RES.0000000000000097
PMID: 27012580
PMCID: PMC5130157
NLM abbreviation: Circ Res
ISSN: 0009-7330
eISSN: 1524-4571
Publisher: United States
Grant note: R01 HL127764 / NHLBI NIH HHS P41 EB015908 / NIBIB NIH HHS MR/P011705/1 / Medical Research Council MC_UP_A090_1006 / Medical Research Council R01 HL112413 / NHLBI NIH HHS RG/13/8/30266 / British Heart Foundation
Language: English
Date published: 05/13/2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984024502502771

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