Journal article
Assessing Low-frequency Repetitive Transcranial Magnetic Stimulation with Functional Magnetic Resonance Imaging: A Case Series
Physiotherapy Research International, Vol.19(2), pp.117-125
06/2014
DOI: 10.1002/pri.518
Abstract
Background and Purpose. This case series assesses the effects of five consecutive days of low-frequency (1Hz) repetitive transcranial magnetic stimulation (rTMS) with and without a 6-Hz primer. Although this paper studies able-bodied individuals, similar rTMS protocols are used to facilitate motor recovery in patients with hemiplegia following stroke. However, the cortical mechanisms associated with repeated daily doses of rTMS are not completely understood. Case Description. Four right-handed healthy volunteers (two men, aged 20-50years) participated in a double-blind case series of primed and unprimed rTMS. Functional magnetic resonance imaging was used to compare task-related haemodynamics during a simple motor task and resting-state cortical connectivity. Understanding the mechanisms of repeated rTMS sessions may serve as a precursor to development of rTMS paradigms involving motor cortex stimulation in patients with a range of neurologic dysfunction. Outcomes. Following five consecutive days of rTMS, all subjects had reduced task-related haemodynamics. Resting-state brain connectivity between motor regions was reduced only after primed rTMS. Discussion. This is the first study to indicate that resting-state brain connectivity can distinguish the effect of primed and unprimed rTMS to a greater extent than task-related haemodynamics. Furthermore, priming may inhibit the connectivity between the area of the cortex underlying the rTMS site and remote brain regions. Significance. These findings benefit rTMS rehabilitation studies by examining haemodynamics on repeated days of stimulation and incorporating resting-state brain connectivity analysis to further understand underlying neural mechanisms. Furthermore, this work encourages the utilization of resting connectivity in future rTMS studies. © 2011 John Wiley & Sons, Ltd.
Details
- Title: Subtitle
- Assessing Low-frequency Repetitive Transcranial Magnetic Stimulation with Functional Magnetic Resonance Imaging: A Case Series
- Creators
- Christopher B Glielmi - Georgia Institute of TechnologyAndrew J Butler - Emory UniversityDmitriy M Niyazov - Georgia Institute of TechnologyWarren G Darling - University of IowaCharles M Epstein - Emory UniversityJay L Alberts - Cleveland ClinicXiaoping P Hu - Georgia Institute of Technology
- Resource Type
- Journal article
- Publication Details
- Physiotherapy Research International, Vol.19(2), pp.117-125
- Publisher
- Blackwell Publishing Ltd
- DOI
- 10.1002/pri.518
- ISSN
- 1358-2267
- eISSN
- 1471-2865
- Number of pages
- 9
- Language
- English
- Date published
- 06/2014
- Academic Unit
- Health and Human Physiology; Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984259392702771
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