Journal article
Assessing bottled water nitrate concentrations to evaluate total drinking water nitrate exposure and risk of birth defects
Journal of water and health, Vol.12(4), pp.755-762
12/2014
DOI: 10.2166/wh.2014.237
PMCID: PMC5072402
PMID: 25473985
Abstract
Previous epidemiologic studies of maternal exposure to drinking water nitrate did not account for bottled water consumption. The objective of this National Birth Defects Prevention Study (NBDPS) (USA) analysis was to assess the impact of bottled water use on the relation between maternal exposure to drinking water nitrate and selected birth defects in infants born during 1997-2005. Prenatal residences of 1,410 mothers reporting exclusive bottled water use were geocoded and mapped; 326 bottled water samples were collected and analyzed using Environmental Protection Agency Method 300.0. Median bottled water nitrate concentrations were assigned by community; mothers' overall intake of nitrate in mg/day from drinking water was calculated. Odds ratios for neural tube defects, limb deficiencies, oral cleft defects, and heart defects were estimated using mixed-effects models for logistic regression. Odds ratios (95% CIs) for the highest exposure group in offspring of mothers reporting exclusive use of bottled water were: neural tube defects [1.42 (0.51, 3.99)], limb deficiencies [1.86 (0.51, 6.80)], oral clefts [1.43 (0.61, 3.31)], and heart defects [2.13, (0.87, 5.17)]. Bottled water nitrate had no appreciable impact on risk for birth defects in the NBDPS.
Details
- Title: Subtitle
- Assessing bottled water nitrate concentrations to evaluate total drinking water nitrate exposure and risk of birth defects
- Creators
- Peter J Weyer - Center for Health Effects of Environmental Contamination, University of Iowa, Iowa City, Iowa, USA E-mail: peter-weyer@uiowa.eduJean D Brender - Department of Epidemiology and Biostatistics, School of Rural Public Health, Texas A&M Health Science Center, Texas A&M University, College Station, Texas, USAPaul A Romitti - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USAJiji R Kantamneni - Center for Health Effects of Environmental Contamination, University of Iowa, Iowa City, Iowa, USA E-mail: peter-weyer@uiowa.eduDavid Crawford - Center for Health Effects of Environmental Contamination, University of Iowa, Iowa City, Iowa, USA E-mail: peter-weyer@uiowa.eduJoseph R Sharkey - Department of Health Promotion and Community Health Sciences, School of Rural Public Health, Texas A&M Health Science Center, College Station, Texas, USAMayura Shinde - Department of Epidemiology and Biostatistics, School of Rural Public Health, Texas A&M Health Science Center, Texas A&M University, College Station, Texas, USAScott A Horel - Department of Epidemiology and Biostatistics, School of Rural Public Health, Texas A&M Health Science Center, Texas A&M University, College Station, Texas, USAAnn M Vuong - Department of Epidemiology and Biostatistics, School of Rural Public Health, Texas A&M Health Science Center, Texas A&M University, College Station, Texas, USAPeter H Langlois - Texas Department of State Health Services, Austin, Texas, USA
- Resource Type
- Journal article
- Publication Details
- Journal of water and health, Vol.12(4), pp.755-762
- Publisher
- England
- DOI
- 10.2166/wh.2014.237
- PMID
- 25473985
- PMCID
- PMC5072402
- ISSN
- 1477-8920
- eISSN
- 1996-7829
- Grant note
- U01 DD000494 / NCBDD CDC HHS 3R01ES015634-03S1 / NIEHS NIH HHS U01DD00494 / NCBDD CDC HHS R01 ES015634 / NIEHS NIH HHS 5R01ES015634 / NIEHS NIH HHS
- Language
- English
- Date published
- 12/2014
- Academic Unit
- Occupational and Environmental Health; Epidemiology; Biostatistics
- Record Identifier
- 9983995002302771
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