Journal article
Assessing the association of epigenetic age acceleration with osteoarthritis in the Multicenter Osteoarthritis Study (MOST)
Osteoarthritis and cartilage, Vol.32(5), pp.585-591
05/2024
DOI: 10.1016/j.joca.2023.11.024
PMCID: PMC11131410
PMID: 38242313
Abstract
Advancing age is one of the strongest risk factors for osteoarthritis (OA). DNA methylation-based measures of epigenetic age acceleration may provide insights into mechanisms underlying OA.
We analyzed data from the Multicenter Osteoarthritis Study (MOST) in a subset of 671 participants ages 45-69 years with no or mild radiographic knee OA. DNA methylation was assessed with the Illumina Infinium MethylationEPIC 850K array. We calculated predicted epigenetic age according to Hannum, Horvath, PhenoAge, and GrimAge epigenetic clocks, then regressed epigenetic age on chronological age to obtain the residuals. Associations between the residuals and knee, hand, and multi-joint OA were assessed using logistic regression, adjusted for chronological age, sex, clinical site, smoking status, and race.
Twenty three percent met criteria for radiographic hand OA, 25% met criteria for radiographic knee OA, and 8% met criteria for multi-joint OA. Mean chronological age (SD) was 58.4 (6.7) years. Mean predicted epigenetic age (SD) according to Horvath, Hannum, PhenoAge, and GrimAge epigenetic clocks was 64.9 (6.4), 68.6 (5.9), 50.5 (7.7), and 67.0 (6.2), respectively. Horvath epigenetic age acceleration was not associated with an increased odds of hand OA, OR (95% CI)=1.03 (0.99-1.08), with similar findings for knee and multi-joint OA. We found similar magnitudes of associations for Hannum epigenetic age, PhenoAge, and GrimAge acceleration compared to Horvath epigenetic age acceleration.
Epigenetic age acceleration as measured by various well-validated epigenetic clocks based on DNA methylation was not associated with increased risk of knee, hand, or multi-joint OA independent of chronological age.
Details
- Title: Subtitle
- Assessing the association of epigenetic age acceleration with osteoarthritis in the Multicenter Osteoarthritis Study (MOST)
- Creators
- Michelle S YauPaul C Okoro - Hebrew SeniorLifeIda K Haugen - Diakonhjemmet HospitalJohn A Lynch - University of California, San FranciscoMichael C Nevitt - University of California, San FranciscoCora E Lewis - University of AlabamaJames C Torner - University of IowaDavid T Felson - Boston University School of Medicine
- Resource Type
- Journal article
- Publication Details
- Osteoarthritis and cartilage, Vol.32(5), pp.585-591
- DOI
- 10.1016/j.joca.2023.11.024
- PMID
- 38242313
- PMCID
- PMC11131410
- NLM abbreviation
- Osteoarthritis Cartilage
- eISSN
- 1522-9653
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000016, name: U.S. Department of Health and Human Services; DOI: 10.13039/100008893, name: University of Iowa, award: U01 AG18947, U01 AG19069; DOI: 10.13039/501100002855, name: Ministry of Science and Technology of the People's Republic of China, award: P30 AR072571, R01 AR075356, U01 AG18820, U01 AG18832
- Language
- English
- Electronic publication date
- 01/17/2024
- Date published
- 05/2024
- Academic Unit
- Neurology; Epidemiology; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9984548298302771
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