Journal article
Assessment and validation of a hygroscopic growth model with different water activity estimation methods
Aerosol science and technology, Vol.54(10), pp.1169-1182
10/02/2020
DOI: 10.1080/02786826.2020.1763247
PMID: 33100458
Abstract
Hygroscopic growth models are currently of interest as aids for targeting the deposition of inhaled drug particles in preferred areas of the lung that will maximize their pharmaceutical effect. Mathematical models derived to estimate hygroscopic growth over time have been previously developed but have not been thoroughly validated. For this study, model validation involved a comparison of modeled values to measured values when the growing droplet had reached equilibrium. A second validation process utilized a novel system to measure the growth of a droplet on a microscope coverslip relative to modeled values when the droplet is undergoing the initial rapid growth phase. Various methods currently used to estimate the water activity of the growing droplet, which influences the droplet growth rate, were also compared. Results indicated that a form of the hygroscopic growth model that utilizes coupled-differential equations to estimate droplet diameter and temperature over time was valid throughout droplet growth until it reached its equilibrium size. Accuracy was enhanced with the use of a polynomial expression to estimate water activity relative to the use of a simplified estimate of water activity based on Raoult's Law. Model accuracy was also improved when constraining the film of salt solution surrounding the dissolving salt core at saturation.
Copyright © 2020 American Association for Aerosol Research
Details
- Title: Subtitle
- Assessment and validation of a hygroscopic growth model with different water activity estimation methods
- Creators
- Patrick T O'Shaughnessy - Department of Occupational & Environmental Health, University of IowaLawrence LeBlanc - Department of Mechanical Engineering, University of IowaAlessandra Pratt - Department of Occupational & Environmental Health, University of IowaRalph Altmaier - Department of Occupational & Environmental Health, University of IowaPrathish K Rajaraman - Department of Mechanical Engineering, University of IowaRoss Walenga - Division of Quantitative Methods and Modeling, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug AdministrationChing-Long Lin - Department of Mechanical Engineering, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Aerosol science and technology, Vol.54(10), pp.1169-1182
- DOI
- 10.1080/02786826.2020.1763247
- PMID
- 33100458
- NLM abbreviation
- Aerosol Sci Technol
- ISSN
- 0278-6826
- eISSN
- 1521-7388
- Publisher
- Taylor & Francis
- Grant note
- name: FDA, award: U01-, 37; DOI: 10.13039/100000066, name: NIEHS, award: 05; name: CDC/NIOSH, award: 91; DOI: 10.13039/100005440, name: Center for Scientific Review, award: U01-, 94
- Language
- English
- Date published
- 10/02/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Civil and Environmental Engineering; Occupational and Environmental Health; IIHR--Hydroscience and Engineering; Mechanical Engineering; Internal Medicine
- Record Identifier
- 9984066346602771
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