Assessment of Cognitive Symptoms in Prodromal and Early Huntington Disease

Anthony L Vaccarino; Terrence Sills; Karen E. Anderson; Beth Borowsky; David Craufurd; Joseph Giuliano; LaVonne Goodman; Mark Guttman; Peter Kupchak; Aileen K Ho; Jane S. Paulsen; Julie C Stout; Daniel P van Kammen; Ken Evans

doi:10.1371/currents.RRN1250

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Assessment of Cognitive Symptoms in Prodromal and Early Huntington Disease

Journal article

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Assessment of Cognitive Symptoms in Prodromal and Early Huntington Disease

Anthony L Vaccarino, Terrence Sills, Karen E. Anderson, Beth Borowsky, David Craufurd, Joseph Giuliano, LaVonne Goodman, Mark Guttman, Peter Kupchak, Aileen K Ho, …

PLoS currents, Vol.3, pp.RRN1250-RRN1250

10/25/2011

DOI: 10.1371/currents.RRN1250

PMCID: PMC3201666

PMID: 22120841

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Abstract

The Functional Rating Scale Taskforce for pre-Huntington Disease (FuRST-pHD) is a multinational, multidisciplinary initiative with the goal of developing a data-driven, comprehensive, psychometrically sound, rating scale for assessing symptoms and functional ability in prodromal and early Huntington disease (HD) gene expansion carriers. The process involves input from numerous sources to identify relevant symptom domains, including HD individuals, caregivers, and experts from a variety of fields, as well as knowledge gained from the analysis of data from ongoing large-scale studies in HD using existing clinical scales. This is an iterative process in which an ongoing series of field tests in prodromal (prHD) and early HD individuals provides the team with data on which to make decisions regarding which questions should undergo further development or testing and which should be excluded. We report here the development and assessment of the first iteration of interview questions aimed to assess cognitive symptoms in prHD and early HD individuals.

Huntington Disease

Details

Title: Subtitle: Assessment of Cognitive Symptoms in Prodromal and Early Huntington Disease
Creators: Anthony L Vaccarino - Research Methods, Ontario Cancer Biomarker Network, Toronto, Ontario, Canada
Terrence Sills - Research Methods, Ontario Cancer Biomarker Network, Toronto, Ontario, Canada
Karen E. Anderson
Beth Borowsky - CHDI Foundation
David Craufurd - University of Manchester
Joseph Giuliano - CHDI Foundation
LaVonne Goodman - Huntington University
Mark Guttman - University of Toronto
Peter Kupchak - Research Methods, Ontario Cancer Biomarker Network, Toronto, Ontario, Canada
Aileen K Ho - University of Reading
Jane S. Paulsen - University of Iowa
Julie C Stout
Daniel P van Kammen - International Drug Development
Ken Evans
Resource Type: Journal article
Publication Details: PLoS currents, Vol.3, pp.RRN1250-RRN1250
Publisher: Public Library of Science
DOI: 10.1371/currents.RRN1250
PMID: 22120841
PMCID: PMC3201666
ISSN: 2157-3999
eISSN: 2157-3999
Language: English
Date published: 10/25/2011
Academic Unit: Psychiatry; Psychological and Brain Sciences
Record Identifier: 9984383908502771

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