Assessment of Depression, Anxiety and Apathy in Prodromal and Early Huntington Disease

Anthony L Vaccarino; Terrence Sills; Karen E. Anderson; Anne-Catherine Bachoud-Lévi; Beth Borowsky; David Craufurd; Kevin Duff; Joseph Giuliano; Mark Groves; Mark Guttman; Peter Kupchak; Aileen K Ho; Jane S. Paulsen; Kenn Freddy Pedersen; Erik van Duijn; Daniel P van Kammen; Ken Evans

doi:10.1371/currents.RRN1242

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Assessment of Depression, Anxiety and Apathy in Prodromal and Early Huntington Disease

Journal article

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Assessment of Depression, Anxiety and Apathy in Prodromal and Early Huntington Disease

Anthony L Vaccarino, Terrence Sills, Karen E. Anderson, Anne-Catherine Bachoud-Lévi, Beth Borowsky, David Craufurd, Kevin Duff, Joseph Giuliano, Mark Groves, Mark Guttman, …

PLoS currents, Vol.3, pp.RRN1242-RRN1242

06/17/2011

DOI: 10.1371/currents.RRN1242

PMCID: PMC3124013

PMID: 21731882

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Abstract

The Functional Rating Scale Taskforce for pre-Huntington Disease (FuRST-pHD) is a multinational, multidisciplinary initiative with the goal of developing a data-driven, comprehensive, psychometrically sound, rating scale for assessing symptoms and functional ability in prodromal and early Huntington disease (HD) gene expansion carriers. The process involves input from numerous sources to identify relevant symptom domains, including HD individuals, caregivers, and experts from a variety of fields, as well as knowledge gained from the analysis of data from ongoing large-scale studies in HD using existing clinical scales. This is an iterative process in which an ongoing series of field tests in prodromal (prHD) and early HD individuals provides the team with data on which to make decisions regarding which questions should undergo further development or testing and which should be excluded. We report here the development and assessment of the first iteration of interview questions aimed to assess Depression, Anxiety and Apathy in prHD and early HD individuals.

Huntington Disease

Details

Title: Subtitle: Assessment of Depression, Anxiety and Apathy in Prodromal and Early Huntington Disease
Creators: Anthony L Vaccarino - Research Methods, Ontario Cancer Biomarker Network, Toronto, Ontario, Canada
Terrence Sills - University of Maryland, Baltimore
Karen E. Anderson
Anne-Catherine Bachoud-Lévi - Inserm
Beth Borowsky - CHDI Foundation
David Craufurd - University of Manchester
Kevin Duff - University of Utah
Joseph Giuliano - CHDI Foundation
Mark Groves - Mount Sinai Beth Israel
Mark Guttman - University of Toronto
Peter Kupchak - University of Reading
Aileen K Ho - University of Iowa
Jane S. Paulsen - Stavanger University Hospital
Kenn Freddy Pedersen - Leiden University
Erik van Duijn - Leiden University
Daniel P van Kammen - International Drug Development
Ken Evans
Resource Type: Journal article
Publication Details: PLoS currents, Vol.3, pp.RRN1242-RRN1242
DOI: 10.1371/currents.RRN1242
PMID: 21731882
PMCID: PMC3124013
NLM abbreviation: PLoS Curr
ISSN: 2157-3999
eISSN: 2157-3999
Publisher: Public Library of Science
Language: English
Date published: 06/17/2011
Academic Unit: Psychiatry; Psychological and Brain Sciences
Record Identifier: 9984383910202771

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