Assessment of Gadobutrol Safety in Combination with Ionizing Radiation Using a Preclinical MRI-Guided Radiotherapy Model

Michael S Petronek; Emily J Steinbach; Amanda L Kalen; Zachariah J Builta; Cameron M Callaghan; Dan E Hyer; Douglas R Spitz; Ryan T Flynn; John M Buatti; Vincent A Magnotta; Diana Zepeda-Orozco; Joël J St-Aubin; Bryan G Allen

doi:10.1667/RADE-20-00199.1

Back

Assessment of Gadobutrol Safety in Combination with Ionizing Radiation Using a Preclinical MRI-Guided Radiotherapy Model

Journal article

Open access

Peer reviewed

Assessment of Gadobutrol Safety in Combination with Ionizing Radiation Using a Preclinical MRI-Guided Radiotherapy Model

Michael S Petronek, Emily J Steinbach, Amanda L Kalen, Zachariah J Builta, Cameron M Callaghan, Dan E Hyer, Douglas R Spitz, Ryan T Flynn, John M Buatti, Vincent A Magnotta, …

Radiation research, Vol.195(3), pp.230-234

03/01/2021

DOI: 10.1667/RADE-20-00199.1

PMCID: PMC8011992

PMID: 33347596

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/8011992View

Open Access

Abstract

MR-linac technology enhances the precision of therapeutic radiation by clarifying the tumor-normal tissue interface and provides the potential for adaptive treatment planning. Accurate delineation of tumors on diagnostic magnetic resonance imaging (MRI) frequently requires gadolinium-based contrast agents (GBCAs). Despite generally being considered safe, previous literature suggests that GBCAs are capable of contrast-induced acute kidney injury (AKI). It is unclear if the risk for AKI is enhanced when GBCAs are administered concurrently with ionizing radiotherapy. During irradiation, gadolinium may be liberated from its chelator which may induce AKI. The goal of this work was to determine if radiation combined with GBCAs increased the incidence of AKI. Using a preclinical MRI-guided irradiation system, where MRI acquisitions and radiation delivery are performed in rapid succession, tumor-bearing mice with normal kidney function were injected with GBCA and treated with 2, 8 or 18 Gy irradiation. Renal function was assessed on days three and seven postirradiation to assess for AKI. No clinically relevant changes in blood urea nitrogen and creatinine were observed in any combination of GBCA and radiation dose. From these data, we conclude that GBCA in combination with radiation does not increase the risk for AKI in mice. Additional investigation of multiple doses of GBCA administered concurrently with irradiation is warranted to evaluate the risk of chronic kidney injury.

Magnetic Resonance Imaging

Brain - diagnostic imaging

Gadolinium - pharmacology

Kidney - pathology

Humans

Contrast Media - pharmacology

Contrast Media - adverse effects

Kidney - diagnostic imaging

Acute Kidney Injury - chemically induced

Radiotherapy, Image-Guided - adverse effects

Disease Models, Animal

Radiation, Ionizing

Kidney - drug effects

Organometallic Compounds - adverse effects

Brain - radiation effects

Gadolinium - adverse effects

Acute Kidney Injury - physiopathology

Brain - drug effects

Kidney - radiation effects

Animals

Radiotherapy, Image-Guided - methods

Brain - pathology

Mice

Acute Kidney Injury - diagnostic imaging

Organometallic Compounds - pharmacology

Details

Title: Subtitle: Assessment of Gadobutrol Safety in Combination with Ionizing Radiation Using a Preclinical MRI-Guided Radiotherapy Model
Creators: Michael S Petronek - Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
Emily J Steinbach - Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
Amanda L Kalen - Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
Zachariah J Builta - Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
Cameron M Callaghan - Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
Dan E Hyer - Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
Douglas R Spitz - Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
Ryan T Flynn - Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
John M Buatti - Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
Vincent A Magnotta - Department of Radiology, University of Iowa, Iowa City, Iowa
Diana Zepeda-Orozco - Department of Pediatrics, The Ohio State University, Columbus, Ohio
Joël J St-Aubin - Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
Bryan G Allen - Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Radiation research, Vol.195(3), pp.230-234
DOI: 10.1667/RADE-20-00199.1
PMID: 33347596
PMCID: PMC8011992
NLM abbreviation: Radiat Res
ISSN: 0033-7587
eISSN: 1938-5404
Publisher: United States
Grant note: T32 CA078586 / NCI NIH HHS R01 CA182804 / NCI NIH HHS P01 CA217797 / NCI NIH HHS P30 CA086862 / NCI NIH HHS R01 CA169046 / NCI NIH HHS
Language: English
Date published: 03/01/2021
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Pathology; Iowa Neuroscience Institute; Radiation Oncology; Neurosurgery; Otolaryngology
Record Identifier: 9984066136102771

Metrics

23 Record Views

6 Times Cited - Web of Science