Assessment of Motor Symptoms and Functional Impact in Prodromal and Early Huntington Disease

Anthony L Vaccarino; Terrence Sills; Karen E. Anderson; Kevin Biglan; Beth Borowsky; Joseph Giuliano; Mark Guttman; Aileen K Ho; Christopher Kennard; Peter Kupchak; G. Bernhard Landwehrmeyer; Andrew Michell; Jane S. Paulsen; Ralf Reilmann; Daniel P van Kammen; John H. Warner; Ken Evans

doi:10.1371/currents.RRN1244

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Assessment of Motor Symptoms and Functional Impact in Prodromal and Early Huntington Disease

Journal article

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Assessment of Motor Symptoms and Functional Impact in Prodromal and Early Huntington Disease

Anthony L Vaccarino, Terrence Sills, Karen E. Anderson, Kevin Biglan, Beth Borowsky, Joseph Giuliano, Mark Guttman, Aileen K Ho, Christopher Kennard, Peter Kupchak, …

PLoS currents, Vol.2, pp.RRN1244-RRN1244

06/14/2011

DOI: 10.1371/currents.RRN1244

PMCID: PMC3114647

PMID: 21804956

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Abstract

The Functional Rating Scale Taskforce for pre-Huntington Disease (FuRST-pHD) is a multinational, multidisciplinary initiative with the goal of developing a data-driven, comprehensive, psychometrically sound, rating scale for assessing symptoms and functional ability in prodromal and early Huntington disease (HD) gene expansion carriers. The process involves input from numerous sources to identify relevant symptom domains, including HD individuals, caregivers, and experts from a variety of fields, as well as knowledge gained from the analysis of data from ongoing large-scale studies in HD using existing clinical scales. This is an iterative process in which an ongoing series of field tests in prodromal (prHD) and early HD individuals provides the team with data on which to make decisions regarding which questions should undergo further development or testing and which should be excluded. We report here the development and assessment of the first iteration of interview questions aimed to assess functional impact of motor manifestations in prHD and early HD individuals.

Huntington Disease

Details

Title: Subtitle: Assessment of Motor Symptoms and Functional Impact in Prodromal and Early Huntington Disease
Creators: Anthony L Vaccarino - Research Methods, Ontario Cancer Biomarker Network, Toronto, Ontario, Canada
Terrence Sills - Research Methods, Ontario Cancer Biomarker Network, Toronto, Ontario, Canada
Karen E. Anderson
Kevin Biglan - University of Rochester
Beth Borowsky - CHDI Foundation
Joseph Giuliano - CHDI Foundation
Mark Guttman - University of Toronto
Aileen K Ho - University of Reading
Christopher Kennard - University of Oxford
Peter Kupchak - Research Methods, Ontario Cancer Biomarker Network, Toronto, Ontario, Canada
G. Bernhard Landwehrmeyer - Universität Ulm
Andrew Michell - University of Cambridge
Jane S. Paulsen - University of Iowa
Ralf Reilmann - University of Münster
Daniel P van Kammen - International Drug Development
John H. Warner
Ken Evans
Resource Type: Journal article
Publication Details: PLoS currents, Vol.2, pp.RRN1244-RRN1244
DOI: 10.1371/currents.RRN1244
PMID: 21804956
PMCID: PMC3114647
NLM abbreviation: PLoS Curr
ISSN: 2157-3999
eISSN: 2157-3999
Publisher: Public Library of Science
Language: English
Date published: 06/14/2011
Academic Unit: Psychiatry; Psychological and Brain Sciences
Record Identifier: 9984383884902771

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