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Assessment of Tedizolid In Vitro Activity and Resistance Mechanisms against a Collection of Enterococcus spp. Causing Invasive Infections, Including Isolates Requiring an Optimized Dosing Strategy for Daptomycin from U.S. and European Medical Centers, 2016 to 2018
Journal article   Peer reviewed

Assessment of Tedizolid In Vitro Activity and Resistance Mechanisms against a Collection of Enterococcus spp. Causing Invasive Infections, Including Isolates Requiring an Optimized Dosing Strategy for Daptomycin from U.S. and European Medical Centers, 2016 to 2018

Cecilia G Carvalhaes, Helio S Sader, Robert K Flamm, Jennifer M Streit and Rodrigo E Mendes
Antimicrobial agents and chemotherapy, Vol.64(4), e00175-20
03/24/2020
DOI: 10.1128/AAC.00175-20
PMCID: PMC7179311
PMID: 32015026

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Abstract

High-level aminoglycoside resistance was noted in 30.0% of and 25.2% of isolates. Only 3.3% and 2.1% of isolates had elevated daptomycin MIC (≥2 mg/liter) and vancomycin resistance, respectively. In contrast, 37.4% to 40.3% of isolates exhibited these phenotypes. Tedizolid inhibited 98.9% to 100.0% of enterococci causing serious invasive infections, including resistant subsets. Oxazolidinone resistance was mainly driven by G2576T; however, and genes were also detected, including in the United States and Turkey.
 Europe United States Anti-Bacterial Agents - pharmacology Daptomycin - pharmacology Drug Resistance, Bacterial - genetics Enterococcus faecalis - drug effects Enterococcus faecalis - genetics Enterococcus faecalis - isolation & purification Enterococcus faecium - drug effects Enterococcus faecium - genetics Enterococcus faecium - isolation & purification Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - microbiology Humans Microbial Sensitivity Tests Oxazolidinones - pharmacology Tetrazoles - pharmacology

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