Assessment of Tedizolid In Vitro Activity and Resistance Mechanisms against a Collection of Enterococcus spp. Causing Invasive Infections, Including Isolates Requiring an Optimized Dosing Strategy for Daptomycin from U.S. and European Medical Centers, 2016 to 2018

Cecilia G Carvalhaes; Helio S Sader; Robert K Flamm; Jennifer M Streit; Rodrigo E Mendes

doi:10.1128/AAC.00175-20

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Assessment of Tedizolid In Vitro Activity and Resistance Mechanisms against a Collection of Enterococcus spp. Causing Invasive Infections, Including Isolates Requiring an Optimized Dosing Strategy for Daptomycin from U.S. and European Medical Centers, 2016 to 2018

Journal article

Open access

Peer reviewed

Assessment of Tedizolid In Vitro Activity and Resistance Mechanisms against a Collection of Enterococcus spp. Causing Invasive Infections, Including Isolates Requiring an Optimized Dosing Strategy for Daptomycin from U.S. and European Medical Centers, 2016 to 2018

Cecilia G Carvalhaes, Helio S Sader, Robert K Flamm, Jennifer M Streit and Rodrigo E Mendes

Antimicrobial agents and chemotherapy, Vol.64(4), e00175-20

03/24/2020

DOI: 10.1128/AAC.00175-20

PMCID: PMC7179311

PMID: 32015026

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https://pmc.ncbi.nlm.nih.gov/articles/PMC7179311/View

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Abstract

High-level aminoglycoside resistance was noted in 30.0% of Enterococcus faecalis and 25.2% of Enterococcus faecium isolates. Only 3.3% and 2.1% of E. faecalis isolates had elevated daptomycin MIC (≥2 mg/liter) and vancomycin resistance, respectively. In contrast, 37.4% to 40.3% of E. faecium isolates exhibited these phenotypes. Tedizolid inhibited 98.9% to 100.0% of enterococci causing serious invasive infections, including resistant subsets. Oxazolidinone resistance was mainly driven by G2576T; however, optrA and poxtA genes were also detected, including poxtA in the United States and Turkey.

Europe

United States

Anti-Bacterial Agents - pharmacology

Daptomycin - pharmacology

Drug Resistance, Bacterial - genetics

Enterococcus faecalis - drug effects

Enterococcus faecalis - genetics

Enterococcus faecalis - isolation & purification

Enterococcus faecium - drug effects

Enterococcus faecium - genetics

Enterococcus faecium - isolation & purification

Gram-Positive Bacterial Infections - drug therapy

Gram-Positive Bacterial Infections - microbiology

Humans

Microbial Sensitivity Tests

Oxazolidinones - pharmacology

Tetrazoles - pharmacology

Details

Title: Subtitle: Assessment of Tedizolid In Vitro Activity and Resistance Mechanisms against a Collection of Enterococcus spp. Causing Invasive Infections, Including Isolates Requiring an Optimized Dosing Strategy for Daptomycin from U.S. and European Medical Centers, 2016 to 2018
Creators: Cecilia G Carvalhaes - JMI Laboratories
Helio S Sader - JMI Laboratories
Robert K Flamm - JMI Laboratories
Jennifer M Streit - JMI Laboratories
Rodrigo E Mendes - JMI Laboratories
Resource Type: Journal article
Publication Details: Antimicrobial agents and chemotherapy, Vol.64(4), e00175-20
DOI: 10.1128/AAC.00175-20
PMID: 32015026
PMCID: PMC7179311
NLM abbreviation: Antimicrob Agents Chemother
ISSN: 0066-4804
eISSN: 1098-6596
Language: English
Date published: 03/24/2020
Academic Unit: Pathology
Record Identifier: 9984185273902771

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