Journal article
Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates: Design of a Retrospective Cohort Study
Frontiers in pediatrics, Vol.4, pp.68-68
2016
DOI: 10.3389/fped.2016.00068
PMCID: PMC4950470
PMID: 27486571
Abstract
Acute kidney injury (AKI) affects ~30% of hospitalized neonates. Critical to advancing our understanding of neonatal AKI is collaborative research among neonatologists and nephrologists. The Neonatal Kidney Collaborative (NKC) is an international, multidisciplinary group dedicated to investigating neonatal AKI. The AWAKEN study (Assessment of Worldwide Acute Kidney injury Epidemiology in Neonates) was designed to describe the epidemiology of neonatal AKI, validate the definition of neonatal AKI, identify primary risk factors for neonatal AKI, and investigate the contribution of fluid management to AKI events and short-term outcomes.
The NKC was established with at least one pediatric nephrologist and neonatologist from 24 institutions in 4 countries (USA, Canada, Australia, and India). A Steering Committee and four subcommittees were created. The database subcommittee oversaw the development of the web-based database (MediData Rave™) that captured all NICU admissions from 1/1/14 to 3/31/14. Inclusion and exclusion criteria were applied to eliminate neonates with a low likelihood of AKI. Data collection included: (1) baseline demographic information; (2) daily physiologic parameters and care received during the first week of life; (3) weekly "snapshots"; (4) discharge information including growth parameters, final diagnoses, discharge medications, and need for renal replacement therapy; and (5) all serum creatinine values.
AWAKEN was proposed as human subjects research. The study design allowed for a waiver of informed consent/parental permission. NKC investigators will disseminate data through peer-reviewed publications and educational conferences.
The purpose of this publication is to describe the formation of the NKC, the establishment of the AWAKEN cohort and database, future directions, and a few "lessons learned." The AWAKEN database includes ~325 unique variables and >4 million discrete data points. AWAKEN will be the largest, most inclusive neonatal AKI study to date. In addition to validating the neonatal AKI definition and identifying risk factors for AKI, this study will uncover variations in practice patterns related to fluid provision, renal function monitoring, and involvement of pediatric nephrologists during hospitalization. The AWAKEN study will position the NKC to achieve the long-term goal of improving the lives, health, and well-being of newborns at risk for kidney disease.
Details
- Title: Subtitle
- Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates: Design of a Retrospective Cohort Study
- Creators
- Jennifer G Jetton - Stead Family Department of Pediatrics, Division of Nephrology, Dialysis and Transplantation, University of Iowa Children's Hospital , Iowa City, IA , USARonnie Guillet - Department of Pediatrics, Division of Neonatology, University of Rochester Medical Center , Rochester, NY , USADavid J Askenazi - Department of Pediatrics, Division of Nephrology, University of Alabama at Birmingham , Birmingham, AL , USALynn Dill - Department of Pediatrics, Division of Nephrology, University of Alabama at Birmingham , Birmingham, AL , USAJudd Jacobs - Data Management Center, Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH , USAAlison L Kent - Department of Neonatology, Centenary Hospital for Women and Children, Canberra Hospital, Australian National University Medical School , Canberra, ACT , AustraliaDavid T Selewski - Department of Pediatrics and Communicable Diseases, Division of Nephrology, C.S. Mott Children's Hospital, University of Michigan , Ann Arbor, MI , USACarolyn L Abitbol - University of MiamiFredrick J Kaskel - Department of Pediatrics, Division of Nephrology, Children's Hospital at Montefiore, Albert Einstein , Bronx, NY , USAMaroun J Mhanna - Department of Pediatrics, Division of Neonatology, MetroHealth Medical Center, Case Western Reserve University , Cleveland, OH , USANamasivayam Ambalavanan - Department of Pediatrics, Division of Neonatology, University of Alabama at Birmingham , Birmingham, AL , USAJennifer R Charlton - Department of Pediatrics, Division of Nephrology, University of Virginia , Charlottesville, VA , USANeonatal Kidney Collaborative
- Resource Type
- Journal article
- Publication Details
- Frontiers in pediatrics, Vol.4, pp.68-68
- DOI
- 10.3389/fped.2016.00068
- PMID
- 27486571
- PMCID
- PMC4950470
- ISSN
- 2296-2360
- eISSN
- 2296-2360
- Grant note
- R01 HL102497 / NHLBI NIH HHS R01 DK108368 / NIDDK NIH HHS R01 DK049419 / NIDDK NIH HHS
- Language
- English
- Date published
- 2016
- Academic Unit
- Stead Family Department of Pediatrics
- Record Identifier
- 9984093500602771
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