Journal article
Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups
Brain and behavior, Vol.12(1), e2413
12/14/2021
DOI: 10.1002/brb3.2413
PMCID: PMC8785613
PMID: 34907666
Abstract
Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD.
Adult subjects (N = 2229; 56.2% male) aged 18-69 years (mean = 35.6, SD = 11.0) from 21 ENIGMA-PGC PTSD sites underwent T1-weighted brain structural magnetic resonance imaging, and PTSD assessment (PTSD+, n = 884). Previously trained voxel-wise (brainageR) and region-of-interest (BARACUS and PHOTON) machine learning pipelines were compared in a subset of control subjects (n = 386). Linear mixed effects models were conducted in the full sample (those with and without PTSD) to examine the effect of PTSD on brain predicted age difference (brain PAD; brain age - chronological age) controlling for chronological age, sex, and scan site.
BrainageR most accurately predicted brain age in a subset (n = 386) of controls (brainageR: ICC = 0.71, R = 0.72, MAE = 5.68; PHOTON: ICC = 0.61, R = 0.62, MAE = 6.37; BARACUS: ICC = 0.47, R = 0.64, MAE = 8.80). Using brainageR, a three-way interaction revealed that young males with PTSD exhibited higher brain PAD relative to male controls in young and old age groups; old males with PTSD exhibited lower brain PAD compared to male controls of all ages.
Differential impact of PTSD on brain PAD in younger versus older males may indicate a critical window when PTSD impacts brain aging, followed by age-related brain changes that are consonant with individuals without PTSD. Future longitudinal research is warranted to understand how PTSD impacts brain aging across the lifespan.
Details
- Title: Subtitle
- Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups
- Creators
- Ashley N Clausen - Kansas City VA Medical CenterKelene A Fercho - Sioux Falls VA Health Care SystemMolly Monsour - Duke UniversitySeth Disner - Minneapolis VA Health Care SystemLauren Salminen - Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USACourtney C Haswell - Duke UniversityEmily Clarke Rubright - Duke UniversityAmanda A Watts - Duke UniversityM Nicole Buckley - Duke UniversityAdi Maron-Katz - Stanford UniversityAnika Sierk - Charité - Universitätsmedizin BerlinAntje Manthey - Charité - Universitätsmedizin BerlinBenjamin Suarez-Jimenez - New York State Psychiatric Institute, New York, New York, USABunmi O Olatunji - Vanderbilt UniversityChristopher L Averill - Yale UniversityDavid Hofmann - Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Muenster, GermanyDick J Veltman - Amsterdam University Medical CentersElizabeth A Olson - McLean HospitalGen Li - Laboratory for Traumatic Stress Studies, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, ChinaGina L Forster - University of South DakotaHenrik Walter - Charité - Universitätsmedizin BerlinJacklynn Fitzgerald - Marquette UniversityJean Théberge - Lawson Health Research InstituteJeffrey S Simons - Sioux Falls VA Health Care SystemJessica A Bomyea - VA San Diego Healthcare SystemJessie L Frijling - Amsterdam NeuroscienceJohn H Krystal - Yale UniversityJustin T Baker - McLean HospitalK Luan Phan - The Ohio State UniversityKerry Ressler - McLean HospitalLaura K M Han - GGZ inGeestLaura Nawijn - Amsterdam University Medical CentersLauren A M Lebois - McLean HospitalLianne Schmaal - OrygenMaria Densmore - Department of Psychiatry, Western University, London, Ontario, CanadaMartha E Shenton - Brigham and Women's HospitalMirjam van Zuiden - Amsterdam NeuroscienceMurray Stein - UC San Diego Department of Psychiatry, San Deigo, California, USANegar Fani - Emory University School of MedicineRaluca M Simons - University of South DakotaRichard W J Neufeld - Department of Psychology, Western University, London, Ontario, CanadaRuth Lanius - Department of Psychiatry, Western University, London, Ontario, CanadaSanne van Rooij - Emory University School of MedicineSaskia B J Koch - Radboud University NijmegenSerena Bonomo - New York State Psychiatric Institute, New York, New York, USATanja Jovanovic - Wayne State UniversityTerri deRoon-Cassini - Medical College of WisconsinTimothy D Ely - Emory University School of MedicineVincent A Magnotta - University of IowaXiaofu He - New York State Psychiatric Institute, New York, New York, USAChadi G Abdallah - Baylor College of MedicineAmit Etkin - Stanford UniversityChristian Schmahl - Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, GermanyChristine Larson - University of Wisconsin–MilwaukeeIsabelle M Rosso - McLean HospitalJennifer Urbano Blackford - Vanderbilt UniversityJennifer S Stevens - Emory University School of MedicineJudith K Daniels - University of GroningenJulia Herzog - Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, GermanyMilissa L Kaufman - McLean HospitalMiranda Olff - Amsterdam NeuroscienceRichard J Davidson - University of Wisconsin–MadisonScott R Sponheim - Minneapolis VA Health Care SystemSven C Mueller - Universidad de DeustoThomas Straube - Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Muenster, GermanyXi Zhu - New York State Psychiatric Institute, New York, New York, USAYuval Neria - New York State Psychiatric Institute, New York, New York, USALee A Baugh - Sioux Falls VA Health Care SystemJames H Cole - University College LondonPaul M Thompson - Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USARajendra A Morey - GGZ inGeest
- Resource Type
- Journal article
- Publication Details
- Brain and behavior, Vol.12(1), e2413
- DOI
- 10.1002/brb3.2413
- PMID
- 34907666
- PMCID
- PMC8785613
- NLM abbreviation
- Brain Behav
- ISSN
- 2162-3279
- eISSN
- 2162-3279
- Grant note
- U.S. Department of Veterans Affairs SFB/TRR 58 / Deutsche Forschungsgemeinschaft Veterans Affairs Merit Review Program VISN6 MIRECC WA 1539/8-2 / Deutsche Forschungsgemeinschaft F31 MH113271 / NIMH NIH HHS The Netherlands organization for Health Research and Development Canadian Institute for Military and Veteran Health Research R01-MH043454 / NIMH NIH HHS Barlow Family Fund NIH U54 EB020403 from the Big Data to Knowledge (BD2K) program VA Career Development Award W81XWH-10-1-0925 / U.S. Department of Defense German Research Society Anonymous Women's Health Fund 07040 / Brain and Behavior Research Foundation Trauma Scholars Fund Institute of Neurosciences, Mental Health and Addiction NHMRC Career Development Fellowship MRC/UKRI Innovation Fellowship German Federal Ministry of Education and Research Center for Brain and Behavior Research Pilot Grant R01 MH106574 / NIMH NIH HHS W81XWH-08-2-0038 / Congressionally Directed Medical Research Programs Bijzonder Onderzoeksfonds UGent K23MH112873 / NIMH NIH HHS R01 MH106574 / NIH HHS U54 EB020403 / NIBIB NIH HHS C07 / Deutsche Forschungsgemeinschaft CX001600 / NCRR NIH HHS Kasparian Fund Narsad Young Investigator DA 1222/4-1 / Deutsche Forschungsgemeinschaft R01 MH043454 / NIMH NIH HHS Department of Veterans Affairs RR&D NCATS NIH HHS K23 MH112873 / NIMH NIH HHS W81XWH08-2-0159 / U.S. Department of Defense K01MH122774 / NIH HHS K01 MH122774 / NIMH NIH HHS T32-MH018931 / NIMH NIH HHS Academic Medical Center Research Council T32MH13043 / NIMH NIH HHS T32 MH013043 / NIMH NIH HHS NIAAA NIH HHS South Dakota Governor's Research Center Grant T32 MH018931 / NIMH NIH HHS C06 / Deutsche Forschungsgemeinschaft
- Language
- English
- Date published
- 12/14/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984202247802771
Metrics
29 Record Views