Journal article
Assessment of natural killer (NK) and NKT cells in murine spleens and livers
Methods in molecular biology (Clifton, N.J.), Vol.447, pp.259-276
2008
DOI: 10.1007/978-1-59745-242-7_18
PMID: 18369924
Abstract
Natural killer (NK) cells part of innate immunity. NK cells have been assigned numerous functions, including the ability to serve as a bridge between innate and adaptive immunity. In evaluating NK cell function, two pathways need to be examined: their ability to kill certain tumors spontaneously and their ability to secrete cytokines, interferon-gamma (IFN-gamma), in particular. Although NK cells are distinct from T lymphocytes, a new lymphocyte subset, termed NKT cell, has been described. NKT cells express surface markers that are unique to NK cells (e.g., NK1.1) as well as markers that are unique to T cells (e.g., CD3). Most NKT cells recognize glycolipids and are thought to play an important immunoregulatory role. This chapter will detail the methodology needed for examination of NK and NKT cells in mice.
Details
- Title: Subtitle
- Assessment of natural killer (NK) and NKT cells in murine spleens and livers
- Creators
- Michael R Shey - The Iowa City VA Medical Center, Department of Internal Medicine, University of Iowa, Iowa City, IA, USAZuhair K Ballas
- Resource Type
- Journal article
- Publication Details
- Methods in molecular biology (Clifton, N.J.), Vol.447, pp.259-276
- DOI
- 10.1007/978-1-59745-242-7_18
- PMID
- 18369924
- eISBN
- 1597452424; 9781597452427
- ISSN
- 1064-3745
- eISSN
- 1940-6029
- Grant note
- AA014418 / NIAAA NIH HHS
- Language
- English
- Date published
- 2008
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094672802771
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