Journal article
Assessment of risk factors for infantile cataracts using a case-control study, National Birth Defects Prevention Study, 2000–2004
Ophthalmology (Rochester, Minn.), Vol.117(8), pp.1500-1505
08/2010
DOI: 10.1016/j.ophtha.2009.12.026
PMCID: PMC2994269
PMID: 20363508
Abstract
Objective
To identify risk factors for infantile cataracts of unknown etiology.
Design
Case-control study.
Participants
Case infants (n = 152) and control infants (n = 4205) enrolled in the National Birth Defects Prevention Study for birth years 2000–2004.
Methods
Multivariate analysis was performed exploring associations for risk factors for bilateral and unilateral infantile cataracts of unknown etiology.
Main Outcome Measures
Infantile cataracts of unknown etiology.
Results
Maternal interviews were completed for 43 case infants with bilateral and 109 with unilateral infantile cataracts of unknown etiology. Very low birth weight (<1500 g) was associated with both unilateral (adjusted odds ratio [OR], 6.0; 95% confidence interval [CI], 2.2–16.3) and bilateral (OR, 13.2; 95% CI, 4.2–41.1) cataracts, whereas low birth weight (1500–2499 g) was only associated with bilateral cataracts (OR, 3.3; 95% CI, 1.3–8.1). Infants with unilateral cataracts were more likely to be born to primigravid women (OR, 1.6; 95% CI, 1.0–2.7) than women with ≥2 previous pregnancies, although this was of borderline significance. Although not significant, effect estimates were elevated suggesting a possible association between unilateral cataracts and maternal substance abuse during pregnancy, and between bilateral cataracts and urinary tract infection during pregnancy and aspirin use during pregnancy.
Conclusions
Very low birth weight is associated with both bilateral and unilateral cataracts, whereas low birth weight is associated with bilateral cataracts and primigravidity with unilateral cataracts. Other associations, although not statistically significant, suggest risk factors that merit further research.
Details
- Title: Subtitle
- Assessment of risk factors for infantile cataracts using a case-control study, National Birth Defects Prevention Study, 2000–2004
- Creators
- Sasapin G Prakalapakorn - Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia Rollins School of Public Health, Emory University, Atlanta, Georgia National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaSonja A Rasmussen - Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia Rollins School of Public Health, Emory University, Atlanta, Georgia National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaScott R Lambert - Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia Rollins School of Public Health, Emory University, Atlanta, Georgia National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaMargaret A Honein - Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia Rollins School of Public Health, Emory University, Atlanta, Georgia National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Ophthalmology (Rochester, Minn.), Vol.117(8), pp.1500-1505
- DOI
- 10.1016/j.ophtha.2009.12.026
- PMID
- 20363508
- PMCID
- PMC2994269
- NLM abbreviation
- Ophthalmology
- ISSN
- 0161-6420
- eISSN
- 1549-4713
- Grant note
- DOI: 10.13039/100000030, name: Centers for Disease Control and Prevention
- Language
- English
- Date published
- 08/2010
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214700702771
Metrics
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