Journal article
Assessment of the New 2012 EULAR/ACR Clinical Classification Criteria for Polymyalgia Rheumatica: A Prospective Multicenter Study
Journal of rheumatology, Vol.43(5), pp.893-900
05/2016
DOI: 10.3899/jrheum.151103
PMID: 26834222
Abstract
To assess the performance of the new 2012 provisional European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) polymyalgia rheumatica (PMR) clinical classification criteria in discriminating PMR from other mimicking conditions compared with the previous 5 diagnostic criteria in a multicenter prospective study.
Patients older than 50 years, presenting with new-onset bilateral shoulder pain with elevated acute-phase reactants (APR), were assessed for the fulfillment of the new and old classification/diagnostic criteria sets for PMR. At the end of the 1-year followup, 133 patients were diagnosed with PMR (expert opinion) and 142 with non-PMR conditions [69 rheumatoid arthritis (RA)]. Discriminating capacity, sensitivity, and specificity of the criteria sets were estimated.
Discriminating capacity of the new clinical criteria for PMR from non-PMR conditions and RA as estimated by area under the curve (AUC) were good with AUC of 0.736 and 0.781, respectively. The new criteria had a sensitivity of 89.5% and a specificity of 57.7% when tested against all non-PMR cases. When tested against all RA, seropositive RA, seronegative RA, and non-RA control patients, specificity changed to 66.7%, 100%, 20.7%, and 49.3%, respectively. Except for the Bird criteria, the 4 previous criteria had lower sensitivity and higher specificity (ranging from 83%-93%) compared with the new clinical criteria in discriminating PMR from all other controls.
The new 2012 EULAR/ACR clinical classification criteria for PMR is highly sensitive; however, its ability to discriminate PMR from other inflammatory/noninflammatory shoulder conditions, especially from seronegative RA, is not adequate. Imaging and other modifications such as cutoff values for APR might increase the specificity of the criteria.
Details
- Title: Subtitle
- Assessment of the New 2012 EULAR/ACR Clinical Classification Criteria for Polymyalgia Rheumatica: A Prospective Multicenter Study
- Creators
- Gulsen Ozen - Ege UniversityNevsun Inanc - Marmara UniversityAli Ugur Unal - Ege UniversitySeda BasGezmis Kimyon - Ege UniversityBunyamin KisacikAhmet Mesut Onat - Ege UniversitySadiye Murat - Gaziantep UniversityHavva Keskin - Ege UniversityMeryem Can - Ege UniversityAlperen Mengi - Ege UniversityNecati CakirAyse BalkarliVeli Cobankara - Ege UniversityNeslihan YilmazAyten YaziciAtalay Dogru - Ege UniversityMehmet Sahin - Ege UniversityAli Sahin - Ege UniversityKevser Gok - Ege UniversitySoner Senel - Ege UniversityOmer Nuri Pamuk - Ege UniversitySema YilmazOzun BayindirKenan Aksu - Ege UniversityYonca Cagatay - Ege UniversityLutfi Akyol - Ege UniversityMehmet SayarliogluGozde Yildirim-Cetin - Ege UniversitySule Yasar-Bilge - Ege UniversityIlker YagciSibel Zehra AydinFatma Alibaz-OnerPamir Atagunduz - Ege UniversityHaner Direskeneli - Marmara University
- Resource Type
- Journal article
- Publication Details
- Journal of rheumatology, Vol.43(5), pp.893-900
- DOI
- 10.3899/jrheum.151103
- PMID
- 26834222
- ISSN
- 0315-162X
- eISSN
- 1499-2752
- Language
- English
- Date published
- 05/2016
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984702825002771
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