Journal article
Assignment of gene responsible for progressive pseudorheumatoid dysplasia to chromosome 6 and examination of COL10A1 as candidate gene
European journal of human genetics : EJHG, Vol.6(3), pp.251-256
06/29/1998
DOI: 10.1038/sj.ejhg.5200187
PMID: 9781029
Abstract
Progressive pseudorheumatoid dysplasia is an autosomal recessive skeletal dysplasia with radiographic changes in the spine similar to Spondyleopiphyseal dysplasia tarda and clinical, though not radiographic resemblance to rheumatoid arthritis. About two-thirds of the reported patients are of Arabic and Mediterranean origin which reflects the relative high incidence in this population. We performed homozygosity mapping utilising the DNA pooling approach to map progressive pseudorheumatoid dysplasia to a chromosomal region on the long arm of chromosome 6. We examined a possible candidate gene in the same region of linkage, namely COL10A1, for alterations in this disorder. We did not identify any mutations in our family, but did not totally exclude COL10A1 gene from being the disease-causing gene.
Details
- Title: Subtitle
- Assignment of gene responsible for progressive pseudorheumatoid dysplasia to chromosome 6 and examination of COL10A1 as candidate gene
- Creators
- Hatem El-ShantiJeffrey C MurrayElena V SeminaKenneth H BeutowTitia ScherpbierJamil Al-Alami
- Resource Type
- Journal article
- Publication Details
- European journal of human genetics : EJHG, Vol.6(3), pp.251-256
- DOI
- 10.1038/sj.ejhg.5200187
- PMID
- 9781029
- NLM abbreviation
- Eur J Hum Genet
- ISSN
- 1018-4813
- eISSN
- 1476-5438
- Language
- English
- Date published
- 06/29/1998
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Medical Genetics and Genomics; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025315702771
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