Journal article
Assisted hatching: trends and pregnancy outcomes, United States, 2000-2010
Fertility and sterility, Vol.102(3), pp.795-801
09/01/2014
DOI: 10.1016/j.fertnstert.2014.06.013
PMCID: PMC4307791
PMID: 25044084
Abstract
Objective: To assess trends and outcomes of assisted hatching among assisted reproductive technology (ART) cycles.
Design: Retrospective cohort analysis using National ART Surveillance System (NASS) data.
Setting: U.S. fertility centers reporting to NASS.
Patient(s): Fresh autologous noncanceled ART cycles conducted from 2000-2010.
Intervention(s): None.
Main Outcome Measure(s): Implantation, clinical pregnancy, live-birth, miscarriage, multiple gestation.
Result(s): Assisted hatching use statistically significantly increased in absolute number (from 25,724 to 35,518 cycles), percentages of day-3 (from 50.7% to 56.3%) and day-5 transfers (from 15.9% to 22.8%), and percentage of transfers among women >= 38 years (from 17.8% to 21.8%) or women with >= 2 prior ART cycles and no live birth(s) (from 4.3% to 7.4%). Both day-3 and day-5 cycles involving assisted hatching were associated with lower odds of implantation (adjusted odds ratios [aOR] 0.7 and 0.6, respectively), clinical pregnancy (aOR 0.8 and 0.7, respectively), live birth (aOR 0.8 and 0.7, respectively), and increased odds of miscarriage (aOR 1.4 and 1.4, respectively), as compared with cycles without assisted hatching. Assisted hatching was associated with lower odds of multiple gestation in day-5 cycles (aOR 0.8). In cycles for women with a "poor prognosis," the association of assisted hatching with pregnancy outcomes was not statistically significant.
Conclusion(s): Assisted hatching use had an increasing trend but was not associated with improved pregnancy outcomes, even in poor-prognosis patients. Prospective studies are needed to identify the patients who may benefit from assisted hatching. (C)2014 by American Society for Reproductive Medicine.
Details
- Title: Subtitle
- Assisted hatching: trends and pregnancy outcomes, United States, 2000-2010
- Creators
- Dmitry M. Kissin - Centers for Disease Control and PreventionJennifer F. Kawwass - National Center for Chronic Disease Prevention and Health PromotionMichael Monsour - National Center for Chronic Disease Prevention and Health PromotionSheree L. Boulet - National Center for Chronic Disease Prevention and Health PromotionDonna R. Session - Emory UniversityDenise J. Jamieson - National Center for Chronic Disease Prevention and Health PromotionNational ART Surveillance System (NASS) Group
- Resource Type
- Journal article
- Publication Details
- Fertility and sterility, Vol.102(3), pp.795-801
- Publisher
- Elsevier
- DOI
- 10.1016/j.fertnstert.2014.06.013
- PMID
- 25044084
- PMCID
- PMC4307791
- ISSN
- 0015-0282
- eISSN
- 1556-5653
- Number of pages
- 7
- Grant note
- CC999999 / Intramural CDC HHS
- Language
- English
- Date published
- 09/01/2014
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446558502771
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