Association Analysis of Candidate Gene Polymorphisms and Audiometric Measures of Noise-Induced Hearing Loss in Young Musicians

Ishan Sunilkumar Bhatt; Raquel Dias; Nilesh Washnik; Jin Wang; O'neil Guthrie; Michael Skelton; Jeffery Lane; Jason Wilder

doi:10.1097/MAO.0000000000002615

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Association Analysis of Candidate Gene Polymorphisms and Audiometric Measures of Noise-Induced Hearing Loss in Young Musicians

Journal article

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Association Analysis of Candidate Gene Polymorphisms and Audiometric Measures of Noise-Induced Hearing Loss in Young Musicians

Ishan Sunilkumar Bhatt, Raquel Dias, Nilesh Washnik, Jin Wang, O'neil Guthrie, Michael Skelton, Jeffery Lane and Jason Wilder

Otology & neurotology, Vol.41(5), pp.e538-e547

06/2020

DOI: 10.1097/MAO.0000000000002615

PMCID: PMC7343220

PMID: 32176153

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Abstract

This study aimed to investigate the association between candidate genetic variants and audiometric measures of noise-induced hearing loss (NIHL) in young musicians. The study analyzed a database by Phillips et al. (Feasibility of a bilateral 4000-6000 Hz notch as a phenotype for genetic association analysis. Int J Audiol 2015;54:645-52.) which included behavioral hearing thresholds, distortion-product otoacoustic emissions (DPOAE), tympanometric, and genetic data of 166 participants meeting the inclusion criteria. Nineteen single nucleotide polymorphisms (SNPs) in 13 cochlear genes previously associated with NIHL in factory workers were included in the present investigation. The average hearing threshold at 3000 and 4000 Hz (AHT) and average DPOAE signal to noise ratio (DPOAE SNR) in both ears were calculated. The regression analyses showed that two SNPs- one in KCNE1 (rs2070358) and the other in CAT (rs12273124) revealed a statistically significant relationship with DPOAE SNR in both ears. Two SNPs in MYH14 and one in GJB4 revealed a significant association with DPOAE SNR in the left ear. Two SNPs in HSP70, one in CDH23 and one in KCNJ10 showed significant association with DPOAE SNR in the right ear. None of the included SNPs showed association with AHT in both ears. A genetic variant in KCNE1 was associated with the strength of the cochlear amplifier as assessed by DPOAE SNR. Musicians carrying causal genetic variants to NIHL might exhibit changes in their auditory functions early in the lifespan even when most subjects had their hearing thresholds within normal limits. These participants are likely to show the clinical manifestation of NIHL in the future if no preventive measures are applied.

Audiometry

Auditory Threshold

Cochlea

Hearing

Hearing Loss, Noise-Induced - genetics

Humans

Otoacoustic Emissions, Spontaneous

Details

Title: Subtitle: Association Analysis of Candidate Gene Polymorphisms and Audiometric Measures of Noise-Induced Hearing Loss in Young Musicians
Creators: Ishan Sunilkumar Bhatt - Northern Arizona University
Raquel Dias - Scripps Health
Nilesh Washnik - Ohio University
Jin Wang - Northern Arizona University
O'neil Guthrie - Northern Arizona University
Michael Skelton - Northern Arizona University
Jeffery Lane - Trinity Hearing Center, Flagstaff, Arizona.
Jason Wilder - Northern Arizona University
Resource Type: Journal article
Publication Details: Otology & neurotology, Vol.41(5), pp.e538-e547
DOI: 10.1097/MAO.0000000000002615
PMID: 32176153
PMCID: PMC7343220
NLM abbreviation: Otol Neurotol
ISSN: 1531-7129
eISSN: 1537-4505
Grant note: U54 CA143925 / NCI NIH HHS R21 DC009296 / NIDCD NIH HHS R21 DC016704 / NIDCD NIH HHS
Language: English
Date published: 06/2020
Academic Unit: Communication Sciences and Disorders
Record Identifier: 9984258742502771

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