Association Between Age and Familial Risk for Alcoholism on Functional Connectivity in Adolescence

Jatin G Vaidya; Alexis L Elmore; Alexander L Wallace; Douglas R Langbehn; John R Kramer; Samuel Kuperman; Daniel S O’Leary

doi:10.1016/j.jaac.2018.12.008

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Association Between Age and Familial Risk for Alcoholism on Functional Connectivity in Adolescence

Journal article

Open access

Peer reviewed

Association Between Age and Familial Risk for Alcoholism on Functional Connectivity in Adolescence

Jatin G Vaidya, Alexis L Elmore, Alexander L Wallace, Douglas R Langbehn, John R Kramer, Samuel Kuperman and Daniel S O’Leary

Journal of the American Academy of Child and Adolescent Psychiatry, Vol.58(7), pp.692-701

07/2019

DOI: 10.1016/j.jaac.2018.12.008

PMCID: PMC7428193

PMID: 30768382

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https://www.ncbi.nlm.nih.gov/pmc/articles/7428193View

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Abstract

Youth with a family history of alcohol use disorder (family history positive [FHP]) are at increased risk for developing maladaptive substance use relative to family history negative (FHN) peers. Building on earlier studies demonstrating morphological differences and distinct patterns of neural activation in FHP, the purpose of the present study was to investigate differential intrinsic functional connectivity among brain networks indexing premorbid risk of developing alcohol use disorder (AUD). The current study examined intrinsic functional connectivity using resting state functional magnetic resonance imaging in 191 adolescents 13 to 18 years of age with and without family history of AUD via independent component analysis, a method enabling data-driven investigation of internetwork and intranetwork connectivity among brain regions at rest. Analyses revealed significantly lower intranetwork connectivity in FHP compared to FHN participants between the dorsal premotor cortex and other sensorimotor network regions. Reduced intranetwork connectivity in this region was further correlated with the number of biological family members with AUD and mood disorders. Robust differences were also evident in internetwork connectivity as a function of age. However, there was no evidence for family history by age interactions. Intra- but not internetwork connectivity appears to differentiate FHP and FHN adolescents, whereas age differences within adolescence are marked by differences in internetwork connectivity.

alcohol

adolescence

resting state

functional connectivity

family history

Details

Title: Subtitle: Association Between Age and Familial Risk for Alcoholism on Functional Connectivity in Adolescence
Creators: Jatin G Vaidya - University of Iowa, Iowa City
Alexis L Elmore - University of Iowa, Iowa City
Alexander L Wallace - University of Wisconsin-Milwaukee, WI
Douglas R Langbehn - University of Iowa, Iowa City
John R Kramer - University of Iowa, Iowa City
Samuel Kuperman - University of Iowa, Iowa City
Daniel S O’Leary - University of Iowa, Iowa City
Resource Type: Journal article
Publication Details: Journal of the American Academy of Child and Adolescent Psychiatry, Vol.58(7), pp.692-701
DOI: 10.1016/j.jaac.2018.12.008
PMID: 30768382
PMCID: PMC7428193
NLM abbreviation: J Am Acad Child Adolesc Psychiatry
ISSN: 0890-8567
eISSN: 1527-5418
Publisher: Elsevier Inc
Grant note: 5R01AA018405 / National Institute on Alcohol Abuse and Alcoholism (https://doi.org/10.13039/100000027)
Language: English
Date published: 07/2019
Academic Unit: Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; University College Courses
Record Identifier: 9984003414702771

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