Journal article
Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults
JAMA neurology, Vol.73(6), pp.721-732
06/01/2016
DOI: 10.1001/jamaneurol.2016.0580
PMCID: PMC5029278
PMID: 27088965
Abstract
The use of anticholinergic (AC) medication is linked to cognitive impairment and an increased risk of dementia. To our knowledge, this is the first study to investigate the association between AC medication use and neuroimaging biomarkers of brain metabolism and atrophy as a proxy for understanding the underlying biology of the clinical effects of AC medications.
Details
- Title: Subtitle
- Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults
- Creators
- Shannon L Risacher - Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indiana University Health Neuroscience Center, Indianapolis2Indiana Alzheimer Disease Center, Indiana University School of Medicine, IndianapolisBrenna C McDonald - Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indiana University Health Neuroscience Center, Indianapolis2Indiana Alzheimer Disease Center, Indiana University School of Medicine, IndianapolisEileen F Tallman - Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indiana University Health Neuroscience Center, Indianapolis2Indiana Alzheimer Disease Center, Indiana University School of Medicine, IndianapolisJohn D West - Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indiana University Health Neuroscience Center, Indianapolis2Indiana Alzheimer Disease Center, Indiana University School of Medicine, IndianapolisMartin R Farlow - Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis3Department of Neurology, Indiana University School of Medicine, IndianapolisFredrick W Unverzagt - Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis4Department of Psychiatry, Indiana University School of Medicine, IndianapolisSujuan Gao - Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis5Department of Biostatistics, Indiana University School of Medicine, IndianapolisMalaz Boustani - Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis6Indiana University Center for Aging Research, Indianapolis7Regenstrief Institute Inc, Indianapolis, Indiana8Eskenzai Health, Indianapolis, IndianaPaul K Crane - Department of Internal Medicine, University of Washington, SeattleRonald C Petersen - Department of Neurology, Mayo Clinic, Rochester, MinnesotaClifford R Jack Jr - Department of Radiology, Mayo Clinic, Rochester, MinnesotaWilliam J Jagust - Department of Neurology, University of California-Berkeley, BerkeleyPaul S Aisen - Alzheimer's Therapeutic Research Institute, University of Southern California, San DiegoMichael W Weiner - Departments of Radiology, Medicine, and Psychiatry, University of California-San Francisco, San Francisco15Department of Veterans Affairs Medical Center, San Francisco, CaliforniaAndrew J Saykin - Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indiana University Health Neuroscience Center, Indianapolis2Indiana Alzheimer Disease Center, Indiana University School of Medicine, IndianapolisAlzheimer’s Disease Neuroimaging Initiative
- Contributors
- HyungSub Shim (Contributor) - University of Iowa, Neurology
- Resource Type
- Journal article
- Publication Details
- JAMA neurology, Vol.73(6), pp.721-732
- Publisher
- United States
- DOI
- 10.1001/jamaneurol.2016.0580
- PMID
- 27088965
- PMCID
- PMC5029278
- ISSN
- 2168-6149
- eISSN
- 2168-6157
- Grant note
- U01 AG006786 / NIA NIH HHS K01 AG049050 / NIA NIH HHS R01 LM011360 / NLM NIH HHS R01 AG011378 / NIA NIH HHS U01 AG024904 / NIA NIH HHS R01 AG044292 / NIA NIH HHS R01 AG021028 / NIA NIH HHS UL1 TR001108 / NCATS NIH HHS U01 AG010483 / NIA NIH HHS RF1 AG031563 / NIA NIH HHS R01 AG041851 / NIA NIH HHS R01 AG032306 / NIA NIH HHS P30 AG010129 / NIA NIH HHS P30 AG010133 / NIA NIH HHS P01 AG019724 / NIA NIH HHS R01 AG031563 / NIA NIH HHS U24 AG021886 / NIA NIH HHS RC2 AG036535 / NIA NIH HHS K01 AG030514 / NIA NIH HHS R01 AG016381 / NIA NIH HHS R01 AG030048 / NIA NIH HHS U01 AG032984 / NIA NIH HHS R01 AG019771 / NIA NIH HHS R01 AG034570 / NIA NIH HHS R01 CA101318 / NCI NIH HHS R01 AG025303 / NIA NIH HHS U19 AG024904 / NIA NIH HHS
- Language
- English
- Date published
- 06/01/2016
- Academic Unit
- Neurology; Psychiatry
- Record Identifier
- 9984020714402771
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