Journal article
Association Between Cardiorespiratory Fitness and Cerebrovascular Reactivity to a Breath Hold Stimulus in Older Adults: Influence of Aerobic Exercise Training
Journal of applied physiology (1985), Vol.132(6), pp.1468-1479
04/28/2022
DOI: 10.1152/japplphysiol.00599.2021
PMCID: PMC9208436
PMID: 35482329
Abstract
Cerebrovascular reactivity (CVR) to a physiological stimulus is a commonly used surrogate of cerebrovascular health. Cross-sectional studies using Blood Oxygen Level Dependent (BOLD) neuroimaging demonstrated lower BOLD-CVR to hypercapnia among adults with high compared with lower cardiorespiratory fitness (CRF) in contrast to transcranial Doppler studies. However, whether BOLD-CVR changes following chronic aerobic exercise in older, cognitively intact adults are unclear. This study evaluated relations between BOLD-CVR with CRF (VO
) using a cross-sectional and interventional study design. We hypothesized that 1) greater CRF would be associated with lower BOLD-CVR in older adults (n=114; 65±6.5 years) with a wide range of CRF; 2) BOLD-CVR would be attenuated after exercise training in a subset (n=33) randomized to 3-months of moderate or light intensity cycling. CVR was quantified as the change in the BOLD signal in response to acute hypercapnia using a blocked breath-hold design from a region-of-interest analysis for cortical networks. In the cross-sectional analysis, there was a quadratic relation between VO
(p=0.03), but not linear (p=0.87), and cortical BOLD-CVR. BOLD-CVR increased until a VO
~28 ml/kg/min after which BOLD-CVR declined. The nonlinear trend was consistent across all networks (p-value=0.04-0.07). In the intervention, both the active and light intensity exercise groups improved CRF similarly (6% vs. 10.8%, p=0.28). The percent change in CRF was positively associated with change in BOLD-CVR in the default mode network only. These data suggest that BOLD-CVR is non-linearly associated with CRF and that in lower-fit adults default mode network may be most sensitive to CRF-related increases in BOLD-CVR.
Details
- Title: Subtitle
- Association Between Cardiorespiratory Fitness and Cerebrovascular Reactivity to a Breath Hold Stimulus in Older Adults: Influence of Aerobic Exercise Training
- Creators
- Lyndsey E DuBose - Department of Health and Human Physiology, University of Iowa, Iowa City, Iowa, United StatesTimothy B Weng - University of IowaGary L Pierce - University of IowaConner Wharff - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, United StatesLauren Reist - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, United StatesChase Hamilton - University of IowaAbby O'Deen - University of IowaKaitlyn M Dubishar - Department of Health and Human Physiology, University of Iowa, Iowa City, Iowa, United StatesAbbi D Lane-Cordova - University of IowaMichelle W Voss - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.132(6), pp.1468-1479
- DOI
- 10.1152/japplphysiol.00599.2021
- PMID
- 35482329
- PMCID
- PMC9208436
- NLM abbreviation
- J Appl Physiol (1985)
- eISSN
- 1522-1601
- Grant note
- 5R01 AG055500-04 / HHS | National Institutes of Health (NIH) 1R21 AG043722 / HHS | National Institutes of Health (NIH) 1R21-AG-043722 / HHS | National Institutes of Health (NIH) 5KL2 RR24980-5 / HHS | National Institutes of Health (NIH) U54 TR001013 / NCATS NIH HHS T32AG000279 / HHS | National Institutes of Health (NIH) 1S10OD025025-01 / HHS | National Institutes of Health (NIH) F32 AG071273 / NIA NIH HHS
- Language
- English
- Date published
- 04/28/2022
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984251632102771
Metrics
30 Record Views