Journal article
Association Between Elevated Serum Uric Acid and Vitamin D Insufficiency Among the Middle-Aged and Elderly Population
Turk nefroloji dializ ve transplantasyon dergisi, Vol.25(2), pp.182-186
01/01/2016
DOI: 10.5262/tndt.2016.1002.10
Abstract
OBJECTIVE: Vitamin D insufficiency might have a role in numerous diseases including autoimmune disease, cancer, diabetes mellitus, hypertension and heart diseases. The relationship between vitamin D insufficiency and hyperuricemia has been shown previously but there are conflicting results in studies.
MATERIAL and METHODS: A total of 1562 patients who had serum uric acid and vitamin D levels measured at the same time were enrolled. Patients who were on vitamin D replacement therapy, receiving calcium and/or allopurinol, or had gout and chronic kidney disease were excluded.
RESULTS: Hyperuricemic patients had significantly lower levels of serum vitamin D level compared with normouricemic patients (p< 0.001) whereas there was no difference between the groups in terms of serum calcium, phosphorus, parathormone and alkaline phosphatase. Severe deficiency (25(OH) vitamin D < 10) was significantly more common among patients with hyperuricemia (p< 0.001). When vitamin D levels were analyzed according to age, a significant inverse correlation between vitamin D and serum uric acid level was found in decades 7 and 8. Age, eGFR and vitamin D level below 20 appeared as independent associates of serum uric acid levels.
CONCLUSION: These data suggest that hyperuricemia associates with vitamin D deficiency. Further studies are needed to understand the mechanism underlying this association and its potential clinical implications.
Details
- Title: Subtitle
- Association Between Elevated Serum Uric Acid and Vitamin D Insufficiency Among the Middle-Aged and Elderly Population
- Creators
- Mumtaz Takir - Istanbul Medeniyet UniversityYalcin Solak - Sakarya UniversityAybala Erek - Istanbul Medeniyet UniversityOsman Kostek - Istanbul Medeniyet UniversityAlihan Oral - Istanbul Medeniyet UniversityOmer Celal Elcioglu - Istanbul Medeniyet UniversityAli Bakan - Istanbul Medeniyet UniversityBaris Afsar - Konya State Hosp, Dept Nephrol, Konya, TurkeyAbdullak Ozkok - Istanbul Medeniyet UniversityDiana Jalal - Univ Colorado, Dept Renal Dis & Hypertens, Aurora, CO USARichard J. Johnson - Univ Colorado, Dept Renal Dis & Hypertens, Aurora, CO USAKubra Aydin Bahat - Istanbul Medeniyet UniversityAli Riza Odabas - Istanbul Medeniyet UniversityMehmet Kanbay - Koç University
- Resource Type
- Journal article
- Publication Details
- Turk nefroloji dializ ve transplantasyon dergisi, Vol.25(2), pp.182-186
- Publisher
- Turk Nefroloji Diyaliz Transplantasyon Dergisi
- DOI
- 10.5262/tndt.2016.1002.10
- ISSN
- 1300-7718
- Number of pages
- 5
- Language
- English
- Date published
- 01/01/2016
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984359577002771
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