Journal article
Association Between Postoperative Acute Kidney Injury and Duration of Cardiopulmonary Bypass: A Meta-Analysis
Journal of cardiothoracic and vascular anesthesia, Vol.26(1), pp.64-69
2012
DOI: 10.1053/j.jvca.2011.07.007
PMID: 21924633
Abstract
This meta-analysis examined the association between cardiopulmonary bypass (CPB) time and acute kidney injury (AKI).
Meta-analysis of previously published studies.
Each single-center study was conducted in a surgical intensive care unit and/or academic or university hospital.
Adult patients undergoing heart surgery with CPB.
A systematic literature review was conducted using PubMed, EMBASE, and Cochrane Library databases and Google Scholar from January 1980 through September 2009. Initial search results were refined to include human subjects, age >18 years, randomized controlled trials, and prospective and retrospective cohort studies, meet the Acute Kidney Injury Network definition of renal failure, and report times on CPB.
The length of time on CPB has been implicated as an independent risk factor for development of AKI after CPB (AKI-CPB). The 9 independent studies included in the final meta-analysis had 12,466 patients who underwent CPB. Out of these, 756 patients (6.06%) developed AKI-CPB. In 7 of the 9 studies, the mean CPB times were statistically longer in the AKI-CPB cohort compared with the control group (cohort without AKI). The absolute mean differences in CPB time between the 2 groups were 25.65 minutes with the fixed-effects model and 23.18 minutes with the random-effects model.
Longer CPB times are associated with a higher risk of developing AKI-CPB, which, in turn, has a significant effect on overall mortality as reported by the individual studies.
Details
- Title: Subtitle
- Association Between Postoperative Acute Kidney Injury and Duration of Cardiopulmonary Bypass: A Meta-Analysis
- Creators
- Avinash B Kumar - Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IAManish Suneja - Department of Nephrology, University of Iowa Hospitals and Clinics, Iowa City, IAEmine O Bayman - Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IAGarry D Weide - Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IAMichele Tarasi - Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- Journal of cardiothoracic and vascular anesthesia, Vol.26(1), pp.64-69
- DOI
- 10.1053/j.jvca.2011.07.007
- PMID
- 21924633
- NLM abbreviation
- J Cardiothorac Vasc Anesth
- ISSN
- 1053-0770
- eISSN
- 1532-8422
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2012
- Academic Unit
- Biostatistics; Anesthesia; Internal Medicine
- Record Identifier
- 9983997369702771
Metrics
33 Record Views