Journal article
Association Between Statin Use and Depressive Symptoms in a Large Community-Dwelling Older Population Living in Australia and the USA: A Cross-Sectional Study
CNS drugs, Vol.33(7), pp.685-694
07/01/2019
DOI: 10.1007/s40263-019-00633-3
PMCID: PMC6719539
PMID: 31062260
Abstract
BackgroundStatin use has been frequently associated with depressive symptoms in an older population. However, the nature of this association is uncertain in the literature. In this study, we aimed to investigate the association of statin intake and the prevalence of depressive symptoms in healthy community-dwelling older adults living in Australia and the USA.MethodsWe analysed baseline data from 19,114 participants, over 70years of age (over 65years of age, if from an ethnic minority). The association of self-reported statin use and prevalenceof depressive symptoms, as measured by a validated depression scale [Center for Epidemiological Studies Depression Scale (CES-D 10)], was determined using logistic regression models. Multivariable logistic models were implemented to account for important demographics and other lifestyle and socioeconomic factors, such as sex, age, living status, education and smoking history.ResultsA total of 5987 individuals were statin users. Of those, 633 (10.6%) had depressive symptoms (CES-D 10 cut-off >= 8), compared with 1246 (9.5%) of the non-statin users. In the unadjusted model, statin use was associated with an increase in prevalence of depressive symptoms (odds ratio 1.13, confidence interval 1.02-1.25, p=0.02). However, after adjusting for important demographic and socioeconomic factors, the use of statins was not significantly associated with depressive symptoms (odds ratio 1.09, confidence interval 0.98-1.20, p=0.11). In secondary analyses, only simvastatin was marginally associated with an increased prevalence of depressive symptoms. Statins were associated with a decreased prevalence of depressive symptoms in individuals with severe obesity (body mass index >35kg/m(2)) and an increased prevalence in participants between 75 and 84years of age.ConclusionThis study in a large community-dwelling older population did not show any association of statins with late-life depressive symptoms, after accounting for important socioeconomic and demographic factors. Confounding by indication is an important issue to be addressed in future pharmacoepidemiologic studies of statins.
Details
- Title: Subtitle
- Association Between Statin Use and Depressive Symptoms in a Large Community-Dwelling Older Population Living in Australia and the USA: A Cross-Sectional Study
- Creators
- Bruno Agustini - Deakin UniversityMohammadreza Mohebbi - Deakin UniversityRobyn L. Woods - Monash UniversityJohn J. McNeil - Monash UniversityMark R. Nelson - Menzies Research InstituteRaj C. Shah - Rush University Medical CenterAnne M. Murray - Berman Center for Outcomes and Clinical ResearchMichael E. Ernst - University of IowaChristopher M. Reid - Monash UniversityAndrew Tonkin - Monash UniversityJessica E. Lockery - Monash UniversityMichael Berk - Florey Institute of Neuroscience and Mental HealthASPREE Investigator Group
- Resource Type
- Journal article
- Publication Details
- CNS drugs, Vol.33(7), pp.685-694
- DOI
- 10.1007/s40263-019-00633-3
- PMID
- 31062260
- PMCID
- PMC6719539
- NLM abbreviation
- CNS Drugs
- ISSN
- 1172-7047
- eISSN
- 1179-1934
- Publisher
- Springer Nature
- Number of pages
- 10
- Grant note
- APP1045862 / NHMRC Senior Research Fellowship; National Health and Medical Research Council (NHMRC) of Australia U01AG029824 / National Cancer Institute at the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) U01AG029824; U19AG062682 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Victorian Cancer Agency (Australia) APP1059660; APP1156072 / National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship; National Health and Medical Research Council (NHMRC) of Australia Monash University (Australia); Monash University 334047; 1127060 / National Health and Medical Research Council of Australia; National Health and Medical Research Council (NHMRC) of Australia
- Language
- English
- Date published
- 07/01/2019
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984297440402771
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