Journal article
Association analyses of the serotonin transporter gene with lifetime depression and alcohol dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
Psychiatric genetics, Vol.17(1), pp.35-38
02/2007
DOI: 10.1097/YPG.0b013e328011188b
PMID: 17167343
Abstract
The objective of this study was to analyze association of the serotonin transporter gene 5-HTTLPR polymorphism on lifetime depression and alcohol dependence in the Collaborative Study on the Genetics of Alcoholism sample. We conducted family-based association analyses in 1913 Caucasians genotyped for the 5-HTTLPR polymorphism. We found evidence for association of the short allele with depression, but no evidence of association with alcohol dependence. On the basis of the evidence that the effect of this polymorphism may be moderated by stressful life events, we classified individuals for the presence and/or absence of stress, as defined by unemployment, relationship problems, or poor health. The evidence for the association with lifetime depression was limited to the group of individuals who had experienced stress, paralleling the direction of effects originally reported by Caspi and colleagues. No evidence was found for the association with alcohol dependence in either the stress or the no-stress groups.
Details
- Title: Subtitle
- Association analyses of the serotonin transporter gene with lifetime depression and alcohol dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
- Creators
- Danielle M Dick - Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri 63110, USA. dickd@wustl.eduJevon PlunkettDamara HamlinJohn Nurnberger JrSam KupermanMarc SchuckitVictor HesselbrockHoward EdenbergLaura Bierut
- Resource Type
- Journal article
- Publication Details
- Psychiatric genetics, Vol.17(1), pp.35-38
- Publisher
- England
- DOI
- 10.1097/YPG.0b013e328011188b
- PMID
- 17167343
- ISSN
- 0955-8829
- eISSN
- 1473-5873
- Grant note
- M01-RR06192 / NCRR NIH HHS U10AA08401 / NIAAA NIH HHS
- Language
- English
- Date published
- 02/2007
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984003460702771
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