Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components

Neil Stahl; Teri G Boulton; Thomas Farruggella; Nancy Y Ip; Sam Davis; Bruce A Witthuhn; Frederick W Quelle; Olli Silvennoinen; Giovanna Barbieri; Sandra Pellegrini; James N Ihle; George D Yancopoulos

doi:10.1126/science.8272873

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Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components

Journal article

Peer reviewed

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components

Neil Stahl, Teri G Boulton, Thomas Farruggella, Nancy Y Ip, Sam Davis, Bruce A Witthuhn, Frederick W Quelle, Olli Silvennoinen, Giovanna Barbieri, Sandra Pellegrini, …

Science (American Association for the Advancement of Science), Vol.263(5143), pp.92-95

1994

DOI: 10.1126/science.8272873

PMID: 8272873

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Abstract

A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor beta components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.

Cell Physiology

Fundamental and applied biological sciences. Psychology

Biological and medical sciences

Responses to growth factors, tumor promotors, other factors

Molecular and cellular biology

Details

Title: Subtitle: Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components
Creators: Neil Stahl - Regeneron Pharmaceuticals, Inc., Tarrytown NY 10591, United States
Teri G Boulton - Regeneron Pharmaceuticals, Inc., Tarrytown NY 10591, United States
Thomas Farruggella - Regeneron Pharmaceuticals, Inc., Tarrytown NY 10591, United States
Nancy Y Ip - Regeneron Pharmaceuticals, Inc., Tarrytown NY 10591, United States
Sam Davis - Regeneron Pharmaceuticals, Inc., Tarrytown NY 10591, United States
Bruce A Witthuhn - St. Jude Children's Research Hospital
Frederick W Quelle - St. Jude Children's Research Hospital
Olli Silvennoinen - St. Jude Children's Research Hospital
Giovanna Barbieri - Institut Pasteur
Sandra Pellegrini - Institut Pasteur
James N Ihle - St. Jude Children's Research Hospital
George D Yancopoulos - Regeneron Pharmaceuticals, Inc., Tarrytown NY 10591, United States
Resource Type: Journal article
Publication Details: Science (American Association for the Advancement of Science), Vol.263(5143), pp.92-95
Publisher: American Association for the Advancement of Science; Washington, DC
DOI: 10.1126/science.8272873
PMID: 8272873
ISSN: 0036-8075
eISSN: 1095-9203
Language: English
Date published: 1994
Academic Unit: Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040323602771

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