Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease

Elizabeth Aylward; James Mills; Dawei Liu; Peggy Nopoulos; Christopher A Ross; Ronald Pierson; Jane S Paulsen

doi:10.1371/currents.RRN1235

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Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease

Journal article

Open access

Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease

Elizabeth Aylward, James Mills, Dawei Liu, Peggy Nopoulos, Christopher A Ross, Ronald Pierson and Jane S Paulsen

PLoS currents, Vol.3, pp.RRN1235-RRN1235

2011

DOI: 10.1371/currents.RRN1235

PMCID: PMC3092625

PMID: 21593963

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Abstract

Background: Longer CAG repeat length is associated with faster clinical progression in Huntington disease, although the effect of higher repeat length on brain atrophy is not well documented. Method: Striatal volumes were obtained from MRI scans of 720 individuals with prodromal Huntington disease. Striatal volume was plotted against age separately for groups with CAG repeat lengths of 38–39, 40, 41, 42, 43, 44, 45, 46, and 47–54. Results: Slopes representing the association between age and striatal volume were significantly steeper as CAG repeat length increased. Discussion: Although cross-sectional, these data suggest that striatal atrophy, like clinical progression, may occur faster with higher CAG repeat lengths.

Huntington Disease

Details

Title: Subtitle: Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease
Creators: Elizabeth Aylward - Division of Neurobiology, Department of Psychiatry, Johns Hopkins University
James Mills - Division of Neurobiology, Department of Psychiatry, Johns Hopkins University
Dawei Liu - Division of Neurobiology, Department of Psychiatry, Johns Hopkins University
Peggy Nopoulos - Division of Neurobiology, Department of Psychiatry, Johns Hopkins University
Christopher A Ross - Division of Neurobiology, Department of Psychiatry, Johns Hopkins University
Ronald Pierson - Division of Neurobiology, Department of Psychiatry, Johns Hopkins University
Jane S Paulsen - Division of Neurobiology, Department of Psychiatry, Johns Hopkins University
Resource Type: Journal article
Publication Details: PLoS currents, Vol.3, pp.RRN1235-RRN1235
DOI: 10.1371/currents.RRN1235
PMID: 21593963
PMCID: PMC3092625
NLM abbreviation: PLoS Curr
ISSN: 2157-3999
eISSN: 2157-3999
Publisher: Public Library of Science
Language: English
Date published: 2011
Academic Unit: Neurology; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984003464002771

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