Journal article
Association between Exposure to Metals during Pregnancy, Childhood Gut Microbiome, and Risk of Intestinal Inflammation in Late Childhood
Environment & health (Washington, D.C.), Vol.2(10), pp.739-749
10/18/2024
DOI: 10.1021/envhealth.4c00125
PMCID: PMC11501044
PMID: 39474439
Abstract
Alterations to the gut microbiome and exposure to metals during pregnancy have been suggested to impact inflammatory bowel disease. Nonetheless, how prenatal exposure to metals eventually results in long-term effects on the gut microbiome, leading to subclinical intestinal inflammation, particularly during late childhood, has not been studied. It is also unknown whether such an interactive effect drives a specific subgroup of children toward elevated susceptibility to intestinal inflammation. We used an amalgamation of machine-learning techniques with a regression-based framework to explore if children with distinct sets of gut microbes and certain patterns of exposure to metals during pregnancy (metal–microbial clique signature) had a higher likelihood of intestinal inflammation, measured based on fecal calprotectin (FC) in late childhood. We obtained samples from a well-characterized longitudinal birth cohort from Mexico City (n = 108), Mexico. In the second and third trimesters of pregnancy, 11 metals were measured in whole blood. Gut microbial abundances and FC were measured in stool samples from children 9–11 years of age. Elevated FC was defined as having FC above 100 μg/g of stool. We identified subgroups of children in whom microbial and metal–microbial clique signatures were associated with elevated FC (false discovery rate (FDR) < 0.05). In particular, we found two metal–microbial clique signatures significantly associated with elevated FC: (1) low cesium (Cs) and copper (Cu) in the third trimester and low relative abundance of Eubacterium ventriosum (OR [95%CI]: 10.27 [3.57,29.52], FDR < 0.001) and (2) low Cu in the third trimester and high relative abundances of Roseburia inulinivorans and Ruminococcus torques (OR [95%CI]: 7.21 [1.81,28.77], FDR < 0.05). This exploratory study demonstrates that children with specific gut microbes and specific exposure patterns to metals during pregnancy may have higher fecal calprotectin levels in late childhood, denoting an elevated risk of intestinal inflammation.
Details
- Title: Subtitle
- Association between Exposure to Metals during Pregnancy, Childhood Gut Microbiome, and Risk of Intestinal Inflammation in Late Childhood
- Creators
- Vishal Midya - Icahn School of Medicine at Mount SinaiManasi Agrawal - Icahn School of Medicine at Mount SinaiJamil M. Lane - Icahn School of Medicine at Mount SinaiChris Gennings - Icahn School of Medicine at Mount SinaiLeonid Tarassishin - Icahn School of Medicine at Mount SinaiLibni A. Torres-Olascoaga - Instituto Nacional de Salud PúblicaJoseph Eggers - University of IowaJill K. Gregory - Icahn School of Medicine at Mount SinaiMellissa Picker - Icahn School of Medicine at Mount SinaiInga Peter - Icahn School of Medicine at Mount SinaiJeremiah J. Faith - Icahn School of Medicine at Mount SinaiManish Arora - Icahn School of Medicine at Mount SinaiMartha M. Téllez-Rojo - Instituto Nacional de Salud PúblicaRobert O. Wright - Icahn School of Medicine at Mount SinaiJean-Frederic Colombel - Icahn School of Medicine at Mount SinaiShoshannah Eggers - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Environment & health (Washington, D.C.), Vol.2(10), pp.739-749
- DOI
- 10.1021/envhealth.4c00125
- PMID
- 39474439
- PMCID
- PMC11501044
- NLM abbreviation
- Environ Health (Wash)
- ISSN
- 2833-8278
- eISSN
- 2833-8278
- Publisher
- AMER CHEMICAL SOC
- Grant note
- National Institute of General Medical SciencesMicrobiome Translational Center at the Icahn School of Medicine at Mount Sinai: UL1TR004419 Clinical and Translational Science Awards (CTSA)National Center for Advancing Translational Sciences: S10OD026880, S10OD030463 Office of Research Infrastructure of the National Institutes of Health
The authors would like to acknowledge the entire PROGRESS study team, particularly Lourdes Schnaas (senior psychologist), as well as the participants. We would also like to thank the Microbiome Translational Center at the Icahn School of Medicine at Mount Sinai. Additionally, this work was supported in part through the computational and data resources and staff expertise provided by Scientific Computing and Data at the Icahn School of Medicine at Mount Sinai and supported by the Clinical and Translational Science Awards (CTSA) Grant UL1TR004419 from the National Center for Advancing Translational Sciences. Research reported in this publication was also supported by the Office of Research Infrastructure of the National Institutes of Health under Awards S10OD026880 and S10OD030463. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
- Language
- English
- Electronic publication date
- 08/08/2024
- Date published
- 10/18/2024
- Academic Unit
- Epidemiology; Injury Prevention Research Center
- Record Identifier
- 9984696808902771
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