Association between Objective Activity Intensity and Heart Rate Variability: Cardiovascular Disease Risk Factor Mediation (CARDIA)

Zachary C Pope; Kelley Pettee Gabriel; Kara M Whitaker; Lin Y Chen; Pamela J Schreiner; David R Jacobs; Barbara Sternfeld; J. Jeffrey Carr; Donald M Lloyd-Jones; Mark A Pereira

doi:10.1249/MSS.0000000000002259

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Association between Objective Activity Intensity and Heart Rate Variability: Cardiovascular Disease Risk Factor Mediation (CARDIA)

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Association between Objective Activity Intensity and Heart Rate Variability: Cardiovascular Disease Risk Factor Mediation (CARDIA)

Zachary C Pope, Kelley Pettee Gabriel, Kara M Whitaker, Lin Y Chen, Pamela J Schreiner, David R Jacobs, Barbara Sternfeld, J. Jeffrey Carr, Donald M Lloyd-Jones and Mark A Pereira

Medicine and science in sports and exercise, Vol.52(6), pp.1314-1321

06/01/2020

DOI: 10.1249/MSS.0000000000002259

PMCID: PMC7275933

PMID: 32427750

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Abstract

Purpose We evaluated the associations between accelerometer-estimated physical activity (PA) intensity and heart rate variability (HRV) and examined mediation of these associations by glycemic control indices and other cardiovascular disease risk factors. Methods Data were from 1668 participants ((X) over bar (age) = 45.9 +/- 3.5 yr, 58.0% female, 39.9% black) who participated in year 20 (2005-2006) of the Coronary Artery Risk Development in Young Adults Fitness Study. The ActiGraph 7164 estimated participants' mean minutes per day of vigorous-intensity PA (VPA), moderate-intensity PA (MPA), and light-intensity PA (LPA) over 7 d. Three sequential 10-s 12-lead ECG strips were used to derive standard deviation of all normal RR intervals (SDNN) and root mean square of all successive RR intervals (rMSSD) HRV. Mediators representing glycemic control indices included fasting glucose, fasting insulin, and 2-h oral glucose tolerance, with other mediators being traditional cardiovascular disease risk factors. Multiple linear regression assessed independent associations of PA intensity with HRV per 1-SD. Mediation analyses computed the proportion of the PA-HRV association attributable to physiological mediators. Results Participants averaged 2.7 +/- 6.2 min center dot d(-1), 33.0 +/- 22.0 min center dot d(-1), and 360.2 +/- 83.8 min center dot d(-1) of VPA, MPA, and LPA, respectively, with mean values for SDNN (32.6 +/- 22.4 ms) and rMSSD (34.0 +/- 24.8 ms) similar. After adjustment for demographic and lifestyle behaviors, VPA was associated with both HRV metrics (SDNN: std beta = 0.06 [0.03, 0.10]; rMSSD: std beta = 0.08 [0.05, 0.12]) and LPA with rMSSD only (std beta = 0.05 [0.01, 0.08]). Fasting insulin and glucose mediated 11.6% to 20.7% of the association of VPA and LPA with HRV, with triglycerides also potentially mediating these associations (range, 9.6%-13.4%). Conclusions Accelerometer-estimated VPA was associated with higher (i.e., improved) HRV. Light-intensity PA also demonstrated a positive association. Mediation analyses suggested these associations may be most attributable to glucose-insulin dynamics.

Life Sciences & Biomedicine

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Title: Subtitle: Association between Objective Activity Intensity and Heart Rate Variability: Cardiovascular Disease Risk Factor Mediation (CARDIA)
Creators: Zachary C Pope - University of Minnesota
Kelley Pettee Gabriel - The University of Texas at Austin
Kara M Whitaker - University of Iowa
Lin Y Chen - University of Minnesota
Pamela J Schreiner - University of Minnesota
David R Jacobs - University of Minnesota
Barbara Sternfeld - Kaiser Permanente
J. Jeffrey Carr - Vanderbilt University Medical Center
Donald M Lloyd-Jones - Northwestern University
Mark A Pereira - University of Minnesota
Resource Type: Journal article
Publication Details: Medicine and science in sports and exercise, Vol.52(6), pp.1314-1321
Publisher: LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/MSS.0000000000002259
PMID: 32427750
PMCID: PMC7275933
ISSN: 0195-9131
eISSN: 1530-0315
Number of pages: 8
Grant note: National Heart, Lung, and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) AG0005 / NHLBI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Intramural Research Program of the National Institute on Aging (NIA) T32 HL007779 / National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) HHSN268201800006I / University of Minnesota; University of Minnesota System AG0005 / NIA; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) HHSN268201800003I / Northwestern University HHSN268201800004I / Kaiser Foundation Research Institute HHSN268201800005I; HHSN268201800007I / University of Alabama at Birmingham R01 HL078972 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
Language: English
Date published: 06/01/2020
Academic Unit: Epidemiology; Health and Human Physiology
Record Identifier: 9984245773502771

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