Journal article
Association between Perinatal Depression and Risk of Attention Deficit Hyperactivity Disorder among Children: A Retrospective Cohort Study
Annals of epidemiology, Vol.63, pp.1-6
06/2021
DOI: 10.1016/j.annepidem.2021.06.005
PMCID: PMC9659329
PMID: 34186179
Abstract
Perinatal depression has previously been identified as a risk factor for attention deficit hyperactivity disorder (ADHD) in the offspring. Population-based studies utilizing diagnosis data are needed to better understand the relationship between these two variables. The objective of this study was to examine the association between perinatal depression and the risk of ADHD among children born during a 5-or-more-year follow-up period.
The sample was drawn from a population-based cohort of privately insured mother-child pairs within the state of Iowa. Hazard ratios for risk of ADHD by exposure to perinatal depression were estimated using adjusted Cox proportional-hazard models.
Among the 5,635 mother-child pairs, 484 mothers were diagnosed with depression during the perinatal period, and 269 children were diagnosed with ADHD. After adjustment for confounders, children born to mothers with perinatal depression were over three times more likely to be diagnosed with ADHD (HR 3.16 (95% CI 2.35, 4.23)).
Children born to mothers with perinatal depression were found to be at increased risk of ADHD. This finding suggests that ADHD and its adverse sequelae could be mitigated by increasing maternal depression intervention efforts as well as ADHD screening and treatment efforts targeted to this vulnerable population.
Details
- Title: Subtitle
- Association between Perinatal Depression and Risk of Attention Deficit Hyperactivity Disorder among Children: A Retrospective Cohort Study
- Creators
- Nichole L Nidey - Cincinnati Children's Hospital Medical Center, Division of Biostatistics and Epidemiology, Cincinnati, OhioAllison M Momany - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IowaLane Strathearn - Center for Disabilities and Development, University of Iowa Stead Family Children's Hospital, Iowa City, IowaKnute D Carter - Department of Biostatistics, University of Iowa College of Public Health, Iowa City, IowaGeorge L Wehby - Department of Health Management and Policy, University of Iowa College of Public Health, Iowa City, IowaWei Bao - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IowaGuifeng Xu - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IowaFrancesca A Scheiber - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IowaKaren Tabb - School of Social Work, University of Illinois at Urbana-Champaign, Urbana, IllinoisTanya E Froehlich - Cincinnati Children's Hospital Medical Center, Division of Developmental and Behavioral Pediatrics, Cincinnati, OhioKelli Ryckman - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Annals of epidemiology, Vol.63, pp.1-6
- DOI
- 10.1016/j.annepidem.2021.06.005
- PMID
- 34186179
- PMCID
- PMC9659329
- NLM abbreviation
- Ann Epidemiol
- ISSN
- 1047-2797
- eISSN
- 1873-2585
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 06/2021
- Academic Unit
- Preventive and Community Dentistry; Psychiatry; Health Management and Policy; Biostatistics; Addiction Medicine; Craniofacial Anomalies Research Center; Developmental and Behavioral Pediatrics; Neonatology; Stead Family Department of Pediatrics; Epidemiology; Economics; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Public Policy Center (Archive)
- Record Identifier
- 9984095142802771
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